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作者:Bogomolov, Marina; Heller, Ruth
作者单位:Technion Israel Institute of Technology; Tel Aviv University
摘要:We consider the problem of identifying whether findings replicate from one study of high dimension to another, when the primary study guides the selection of hypotheses to be examined in the follow-up study as well as when there is no division of roles into the primary and the follow-up study. We show that existing meta-analysis methods are not appropriate for this problem, and suggest novel methods instead. We prove that our multiple testing procedures control for appropriate error rates. The...
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作者:Blei, David M.
作者单位:Princeton University
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作者:Grimmer, Justin
作者单位:Stanford University
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作者:Taddy, Matt
作者单位:University of Chicago
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作者:Li, Bo; Genton, Marc G.
作者单位:Purdue University System; Purdue University; King Abdullah University of Science & Technology
摘要:We propose a unified framework for testing a variety of assumptions commonly made about the structure of copulas, including symmetry, radial symmetry, joint symmetry, associativity and Archimedeanity, and max-stability. Our test is nonparametric and based on the asymptotic distribution of the empirical copula process. We perform simulation experiments to evaluate our test and conclude that our method is reliable and powerful for assessing common assumptions on the structure of copulas, particu...
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作者:Wang, Yueqing; Jiang, Xin; Yu, Bin; Jiang, Ming
作者单位:University of California System; University of California Berkeley; Peking University; University of California System; University of California Berkeley
摘要:Atmospheric aerosols can cause serious damage to human health and reduce life expectancy. Using the radiances observed by NASA's Multi-angle Imaging SpectroRadiometer (MISR), the current MISR operational algorithm retrieves aerosol optical depth (AOD) at 17.6 km resolution. A systematic study of aerosols and their impact on public health, especially in highly populated urban areas, requires finer-resolution estimates of AOD's spatial distribution. We embed MISR's operational weighted least squ...
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作者:Chen, Lisha; Dou, Winston Wei; Qiao, Zhihua
作者单位:Yale University; Massachusetts Institute of Technology (MIT); JP Morgan Chase & Company
摘要:Some existing nonparametric two-sample tests for equality of multivariate distributions perform unsatisfactorily when the two sample sizes are unbalanced. In particular, the power of these tests tends to diminish with increasingly unbalanced sample sizes. In this article, we propose a new testing procedure to solve this problem. The proposed test, based on the nearest neighbor method by Schilling, employs a novel ensemble subsampling scheme to remedy this issue. More specifically, the test sta...
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作者:Liu, Tao; Hogan, Joseph W.; Wang, Lisa; Zhang, Shangxuan; Kantor, Rami
作者单位:Brown University; Memorial Sloan Kettering Cancer Center; Brown University
摘要:The World Health Organization (WHO) guidelines for monitoring the effectiveness of human immunodeficiency virus (HIV) treatment in resource-limited settings are mostly based on clinical and immunological markers (e. g., CD4 cell counts). Recent research indicates that the guidelines are inadequate and can result in high error rates. Viral load (VL) is considered the gold standard, yet its widespread use is limited by cost and infrastructure. In this article, we propose a diagnostic algorithm t...
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作者:Sarkar, Sanat K.; Chen, Jingjing; Guo, Wenge
作者单位:Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; AstraZeneca; Medimmune; New Jersey Institute of Technology
摘要:Testing multiple null hypotheses in two stages to decide which of these can be rejected or accepted at the first stage and which should be followed up for further testing having had additional observations is of importance in many scientific studies. We develop two procedures, each with two different combination functions, Fisher's and Simes', to combine p-values from two stages, given prespecified boundaries on the first-stage p-values in terms of the false discovery rate (FDR) and controllin...
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作者:Zeng, Donglin
作者单位:University of North Carolina; University of North Carolina Chapel Hill