Optimal Allocation of Gold Standard Testing Under Constrained Availability: Application to Assessment of HIV Treatment Failure

• 成果类型: Article
• 署名作者: Liu, Tao; Hogan, Joseph W.; Wang, Lisa; Zhang, Shangxuan; Kantor, Rami
• 署名单位: Brown University; Memorial Sloan Kettering Cancer Center; Brown University
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1080/01621459.2013.810149
• 发表日期: 2013
• 页码: 1173-1188
• 关键词: antiretroviral treatment failure; VIRAL LOAD; virological responses; confidence-intervals; measurement error; prediction; therapy; infection; adherence; adults

摘要

The World Health Organization (WHO) guidelines for monitoring the effectiveness of human immunodeficiency virus (HIV) treatment in resource-limited settings are mostly based on clinical and immunological markers (e. g., CD4 cell counts). Recent research indicates that the guidelines are inadequate and can result in high error rates. Viral load (VL) is considered the gold standard, yet its widespread use is limited by cost and infrastructure. In this article, we propose a diagnostic algorithm that uses information from routinely collected clinical and immunological markers to guide a selective use of VL testing for diagnosing HIV treatment failure, under the assumption that VL testing is available only at a certain portion of patient visits. Our algorithm identifies the patient subpopulation, such that the use of limited VL testing on them minimizes a predefined risk (e. g., misdiagnosis error rate). Diagnostic properties of our proposed algorithm are assessed by simulations. For illustration, data from the Miriam Hospital Immunology Clinic (Providence, RI) are analyzed.