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作者：Franks, Alexander M.; Csardi, Gabor; Drummond, D. Allan; Airoldi, Edoardo M.
作者单位：Harvard University; University of Chicago
摘要：We consider the problem of quantifying the degree of coordination between transcription and translation, in yeast. Several studies have reported a surprising lack of coordination over the years, in organisms as different as yeast and humans, using diverse technologies. However, a close look at this literature suggests that the lack of reported correlation may not reflect the biology of regulation. These reports do not control for between-study biases and structure in the measurement errors, ig...
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作者：Du, Jiejun; Dryden, Ian L.; Huang, Xianzheng
作者单位：University of Nottingham; University of South Carolina System; University of South Carolina Columbia
摘要：We consider the problem of comparing sizes and shapes of objects when landmark data are prone to measurement error. We show that naive implementation of ordinary Procrustes analysis that ignores measurement error can compromise inference. To account for measurement error, we propose the conditional score method for matching configurations, which guarantees consistent inference under mild model assumptions. The effects of measurement error on inference from naive Procrustes analysis and the per...
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作者：Kenah, Eben
作者单位：State University System of Florida; University of Florida
摘要：This article introduces semiparametric relative-risk regression models for infectious disease data. The units of analysis in these models are pairs of individuals at risk of transmission. The hazard of infectious contact from i to j consists of a baseline hazard multiplied by a relative risk function that can be a function of infectiousness covariates for i, susceptibliity covariates for j, and pairwise covariates. When who-infects-whom is observed, we derive a profile likelihood maximized ove...
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作者：Storlie, Curtis B.; Lane, William A.; Ryan, Emily M.; Gattiker, James R.; Higdon, David M.
作者单位：United States Department of Energy (DOE); Los Alamos National Laboratory; Boston University
摘要：It has become commonplace to use complex computer models to predict outcomes in regions where data do not exist. Typically these models need to be calibrated and validated using some experimental data, which often consists of multiple correlated outcomes. In addition, some of the model parameters may be categorical in nature, such as a pointer variable to alternate models (or submodels) for some of the physics of the system. Here, we present a general approach for calibration in such situation...
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作者：Fan, Jianqing; Tong, Xin; Zeng, Yao
作者单位：Princeton University; Capital University of Economics & Business; University of Southern California; Harvard University
摘要：When people in a society want to make inference about some parameter, each person may want to use data collected by other people. Information (data) exchange in social networks is usually costly, so to make reliable statistical decisions, people need to weigh the benefits and costs of information acquisition. Conflicts of interests and coordination problems will arise in the process. Classical statistics does not consider people's incentives and interactions in the data-collection process. To ...
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作者：Ma, Shujie; Song, Peter X. -K.
作者单位：University of California System; University of California Riverside; University of Michigan System; University of Michigan
摘要：It has been a long history of using interactions in regression analysis to investigate alterations in covariate-effects on response variables. In this article, we aim to address two kinds of new challenges arising from the inclusion of such high-order effects in the regression model for complex data. The first kind concerns a situation where interaction effects of individual covariates are weak but those of combined covariates are strong, and the other kind pertains to the presence of nonlinea...
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作者：Heaton, Matthew J.; Sain, Stephan R.; Monaghan, Andrew J.; Wilhelmi, Olga V.; Hayden, Mary H.
作者单位：Brigham Young University; National Center Atmospheric Research (NCAR) - USA
摘要：We analyze an incomplete marked point pattern of heat-related 911 calls between the years 2006-2010 in Houston, TX, to primarily investigate conditions that are associated with increased vulnerability to heat-related morbidity and, secondarily, build a statistical model that can be used as a public health tool to predict the volume of 911 calls given a time frame and heat exposure. We model the calls as arising from a nonhomogenous Cox process with unknown intensity measure. By using the kerne...
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作者：Ke, Zheng Tracy; Fan, Jianqing; Wu, Yichao
作者单位：Princeton University; North Carolina State University
摘要：This article explores the homogeneity of coefficients in high-dimensional regression, which extends the sparsity concept and is more general and suitable for many applications. Homogeneity arises when regression coefficients corresponding to neighboring geographical regions or a similar cluster of covariates are expected to be approximately the same. Sparsity corresponds to a special case of homogeneity with a large cluster of known atom zero. In this article, we propose a new method called cl...
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作者：Hahn, P. Richard; Carvalho, Carlos M.
作者单位：University of Chicago; University of Texas System; University of Texas Austin
摘要：Selecting a subset of variables for linear models remains an active area of research. This article reviews many of the recent contributions to the Bayesian model selection and shrinkage prior literature. A posterior variable selection summary is proposed, which distills a full posterior distribution over regression coefficients into a sequence of sparse linear predictors.
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作者：Tang, Xu; Gan, Fah F.; Zhang, Lingyun
作者单位：National University of Singapore; Beijing Normal-Hong Kong Baptist University
摘要：The cumulative sum charting procedure is traditionally used in the manufacturing industry for monitoring the quality of products. Recently, it has been extended to monitoring surgical outcomes. Unlike a manufacturing process where the raw material is usually reasonably homogeneous, patients' risks of surgical failure are usually different. It has been proposed in the literature that the binary outcomes from a surgical procedure be adjusted using the preoperative risk based on a likelihood-rati...
