-
作者:Pedeli, Xanthi; Davison, Anthony C.; Fokianos, Konstantinos
作者单位:Athens University of Economics & Business; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Cyprus
摘要:Saddlepoint techniques have been used successfully in many applications, owing to the high accuracy with which they can approximate intractable densities and tail probabilities. This article concerns their use for the estimation of high-order integer-valued autoregressive, INAR(p), processes. Conditional least squares estimation and maximum likelihood estimation have been proposed for INAR(p) models, but the first is inefficient for estimating parametric models, and the second becomes difficul...
-
作者:Azriel, David; Schwartzman, Armin
作者单位:Technion Israel Institute of Technology; University of Pennsylvania; North Carolina State University
摘要:Motivated by the advent of high-dimensional, highly correlated data, this work studies the limit behavior of the empirical cumulative distribution function (ecdf) of standard normal random variables under arbitrary correlation. First, we provide a necessary and sufficient condition for convergence of the ecdf to the standard normal distribution. Next, under general correlation, we show that the ecdf limit is a random, possible infinite, mixture of normal distribution functions that depends on ...
-
作者:Finucane, Mariel M.; Paciorek, Christopher J.; Stevens, Gretchen A.; Ezzati, Majid
作者单位:Mathematica; University of California System; University of California Berkeley; World Health Organization; Imperial College London
摘要:Undernutrition, resulting in restricted growth, and quantified here using height-for-age z-scores, is an important contributor to childhood morbidity and mortality. Since all levels of mild, moderate, and severe undemutrition are of clinical and public health importance, it is of interest to estimate the shape of the z-scores' distributions. We present a finite normal mixture model that uses data on 4.3 million children to make annual country-specific estimates of these distributions for under...
-
作者:Hodges, Jim
作者单位:University of Minnesota System; University of Minnesota Twin Cities
-
作者:Hwang, Beom Seuk; Chen, Zhen
作者单位:National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
摘要:In estimating ROC curves of multiple tests, some a priori constraints may exist, either between the healthy and diseased populations within a test or between tests within a population. In this article, we proposed an integrated modeling approach for ROC curves that jointly accounts for stochastic and variability orders. The stochastic order constrains the distributional centers of the diseased and healthy populations within a test, while the variability order constrains the distributional spre...
-
作者:Chen, Hua Yun; Rader, Daniel E.; Li, Mingyao
作者单位:University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Pennsylvania; University of Pennsylvania
摘要:A flexible semiparametric odds ratio model has been proposed to unify and to extend both the log-linear model and the joint normal model for data with a mix of discrete and continuous variables. The semiparametric odds ratio model is particularly useful for analyzing biased sampling designs. However, statistical inference of the model has not been systematically studied when more than one nonparametric component is involved in the model. In this article, we study the maximum semiparametric lik...
-
作者:Hu, Yi-Juan; Sun, Wei; Tzeng, Jung-Ying; Perou, Charles M.
作者单位:Emory University; University of North Carolina; University of North Carolina Chapel Hill; North Carolina State University; National Cheng Kung University; University of North Carolina; University of North Carolina Chapel Hill
摘要:Studies of expression quantitative trait loci (eQTLs) offer insight into the molecular mechanisms of loci that were found to be associated with complex diseases and the mechanisms can be classified into cis- and trans-acting regulation. At present, high-throughput RNA sequencing (RNA-seq) is rapidly replacing expression microarrays to assess gene expression abundance. Unlike microarrays that only measure the total expression of each gene, RNA-seq also provides information on allele-specific ex...
-
作者:Azzimonti, Laura; Sangalli, Laura M.; Secchi, Piercesare; Domanin, Maurizio; Nobile, Fabio
作者单位:Polytechnic University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要:We propose an innovative method for the accurate estimation of surfaces and spatial fields when prior knowledge of the phenomenon under study is available. The prior knowledge included in the model derives from physics, physiology, or mechanics of the problem at hand, and is formalized in terms of a partial differential equation governing the phenomenon behavior, as well as conditions that the phenomenon has to satisfy at the boundary of the problem domain. The proposed models exploit advanced...
-
作者:Blair, Graeme; Imai, Kosuke; Zhou, Yang-Yang
作者单位:Columbia University; Princeton University
摘要:About a half century ago, in 1965, Warner proposed the randomized response method as a survey technique to reduce potential bias due to nonresponse and social desirability when asking questions about sensitive behaviors and beliefs. This method asks respondents to use a randomization device, such as a coin flip, whose outcome is unobserved by the interviewer. By introducing random noise, the method conceals individual responses and protects respondent privacy. While numerous methodological adv...
-
作者:Huang, Chao; Styner, Martin; Zhu, Hongtu
作者单位:University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要:An important goal in image analysis is to cluster and recognize objects of interest according to the shapes of their boundaries. Clustering such objects faces at least four major challenges including a curved shape space, a high-dimensional feature space, a complex spatial correlation structure, and shape variation associated with some covariates (e.g., age or gender). The aim of this article is to develop a penalized model-based clustering framework to cluster landmark-based planar shape data...