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作者：Imai, Kosuke; Jiang, Zhichao
作者单位：Harvard University; Harvard University; University of Massachusetts System; University of Massachusetts Amherst
摘要：We begin by congratulating Yixin Wang and David Blei for their thought-provoking article that opens up a new research frontier in the field of causal inference. The authors directly tackle the challenging question of how to infer causal effects of many treatments in the presence of unmeasured confounding. We expect their article to have a major impact by further advancing our understanding of this important methodological problem. This commentary has two goals. We first critically review the d...
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作者：Huang, Lei; Bai, Jiawei; Ivanescu, Andrada; Harris, Tamara; Maurer, Mathew; Green, Philip; Zipunnikov, Vadim
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Montclair State University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); Columbia University; Columbia University
摘要：The number of studies where the primary measurement is a matrix is exploding. In response to this, we propose a statistical framework for modeling populations of repeatedly observed matrix-variate measurements. The 2D structure is handled via a matrix-variate distribution with decomposable row/column-specific covariance matrices and a linear mixed effect framework is used to model the multilevel design. The proposed framework flexibly expands to accommodate many common crossed and nested desig...
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作者：Kennedy, Edward H.; Harris, Steve; Keele, Luke J.
作者单位：Carnegie Mellon University; University of London; Queen Mary University London; University College London; Georgetown University
摘要：Pretreatment selection or censoring (selection on treatment) can occur when two treatment levels are compared ignoring the third option of neither treatment, in censoring by death settings where treatment is only defined for those who survive long enough to receive it, or in general in studies where the treatment is only defined for a subset of the population. Unfortunately, the standard instrumental variable (IV) estimand is not defined in the presence of such selection, so we consider estima...
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作者：Ni, Yang; Stingo, Francesco C.; Ha, Min Jin; Akbani, Rehan; Baladandayuthapani, Veerabhadran
作者单位：University of Texas System; University of Texas Austin; University of Florence; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
摘要：Identifying patient-specific prognostic biomarkers is of critical importance in developing personalized treatment for clinically and molecularly heterogeneous diseases such as cancer. In this article, we propose a novel regression framework, Bayesian hierarchical varying-sparsity regression (BEHAVIOR) models to select clinically relevant disease markers by integrating proteogenomic (proteomic+genomic) and clinical data. Our methods allow flexible modeling of protein-gene relationships as well ...
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作者：Li, Gang; Wang, Xiaoyan
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：This article develops a pair of new prediction summary measures for a nonlinear prediction function with right-censored time-to-event data. The first measure, defined as the proportion of explained variance by a linearly corrected prediction function, quantifies the potential predictive power of the nonlinear prediction function. The second measure, defined as the proportion of explained prediction error by its corrected prediction function, gauges the closeness of the prediction function to i...
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作者：Knox, Dean; Yamamoto, Teppei; Baum, Matthew A.; Berinsky, Adam J.
作者单位：Princeton University; Massachusetts Institute of Technology (MIT); Harvard University
摘要：Social and medical scientists are often concerned that the external validity of experimental results may be compromised because of heterogeneous treatment effects. If a treatment has different effects on those who would choose to take it and those who would not, the average treatment effect estimated in a standard randomized controlled trial (RCT) may give a misleading picture of its impact outside of the study sample. Patient preference trials (PPTs), where participants' preferences over trea...
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作者：Oates, Chris J.; Cockayne, Jon; Aykroyd, Robert G.; Girolami, Mark
作者单位：Newcastle University - UK; Alan Turing Institute; University of Warwick; University of Leeds; Imperial College London
摘要：The use of high-power industrial equipment, such as large-scale mixing equipment or a hydrocyclone for separation of particles in liquid suspension, demands careful monitoring to ensure correct operation. The fundamental task of state-estimation for the liquid suspension can be posed as a time-evolving inverse problem and solved with Bayesian statistical methods. In this article, we extend Bayesian methods to incorporate statistical models for the error that is incurred in the numerical soluti...
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作者：Xie, Yimeng; Xu, Li; Li, Jie; Deng, Xinwei; Hong, Yili; Kolivras, Korine; Gaines, David N.
作者单位：Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
摘要：Lyme disease is an infectious disease, that is, caused by a bacterium called Borrelia burgdorferi sensu stricto. In the United States, Lyme disease is one of the most common infectious diseases. The major endemic areas of the disease are New England, Mid-Atlantic, East-North Central, South Atlantic, and West North-Central. Virginia is on the front-line of the disease's diffusion from the northeast to the south. One of the research objectives for the infectious disease community is to identify ...
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作者：Antonelli, Joseph; Daniels, Michael J.
作者单位：State University System of Florida; University of Florida
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作者：Spieker, Andrew J.
作者单位：Vanderbilt University
