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作者：Chen, Yuan; Zeng, Donglin; Wang, Yuanjia
作者单位：Columbia University; University of North Carolina; University of North Carolina Chapel Hill
摘要：For many mental disorders, latent mental status from multiple-domain psychological or clinical symptoms may perform as a better characterization of the underlying disorder status than a simple summary score of the symptoms, and they may also serve as more reliable and representative features to differentiate treatment responses. Therefore, to address the complexity and heterogeneity of treatment responses for mental disorders, we provide a new paradigm for learning optimal individualized treat...
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作者：Chen, Ting-Huei; Chatterjee, Nilanjan; Landi, Maria Teresa; Shi, Jianxin
作者单位：Laval University; Johns Hopkins University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Epidemiology & Genetics; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Epidemiology & Genetics
摘要：Large-scale genome-wide association studies (GWAS) provide opportunities for developing genetic risk prediction models that have the potential to improve disease prevention, intervention or treatment. The key step is to develop polygenic risk score (PRS) models with high predictive performance for a given disease, which typically requires a large training dataset for selecting truly associated single nucleotide polymorphisms (SNPs) and estimating effect sizes accurately. Here, we develop a com...
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作者：Yang, Shu; Ding, Peng
作者单位：North Carolina State University; University of California System; University of California Berkeley
摘要：The era of big data has witnessed an increasing availability of multiple data sources for statistical analyses. We consider estimation of causal effects combining big main data with unmeasured confounders and smaller validation data withon these confounders. Under the unconfoundedness assumption with completely observed confounders, the smaller validation data allow for constructing consistent estimators for causal effects, but the big main data can only give error-prone estimators in general....
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作者：Sung, Chih-Li; Hung, Ying; Rittase, William; Zhu, Cheng; Wu, C. F. J.
作者单位：Michigan State University; Rutgers University System; Rutgers University New Brunswick; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
摘要：Calibration refers to the estimation of unknown parameters which are present in computer experiments but not available in physical experiments. An accurate estimation of these parameters is important because it provides a scientific understanding of the underlying system which is not available in physical experiments. Most of the work in the literature is limited to the analysis of continuous responses. Motivated by a study of cell adhesion experiments, we propose a new calibration framework f...
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作者：Castro-Camilo, Daniela; Huser, Raphael
作者单位：King Abdullah University of Science & Technology; University of Glasgow
摘要：To disentangle the complex nonstationary dependence structure of precipitation extremes over the entire contiguous United States (U.S.), we propose a flexible local approach based on factor copula models. Our subasymptotic spatial modeling framework yields nontrivial tail dependence structures, with a weakening dependence strength as events become more extreme; a feature commonly observed with precipitation data but not accounted for in classical asymptotic extreme-value models. To estimate th...
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作者：Simoneau, Gabrielle; Moodie, Erica E. M.; Nijjar, Jagtar S.; Platt, Robert W.
作者单位：McGill University; University of Cambridge
摘要：The statistical study of precision medicine is concerned with dynamic treatment regimes (DTRs) in which treatment decisions are tailored to patient-level information. Individuals are followed through multiple stages of clinical intervention, and the goal is to perform inferences on the sequence of personalized treatment decision rules to be applied in practice. Of interest is the identification of an optimal DTR, that is, the sequence of treatment decisions that yields the best expected outcom...
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作者：Zheng, Chaowen; Wu, Yichao
作者单位：North Carolina State University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要：A multivariate mixture model is determined by three elements: the number of components, the mixing proportions, and the component distributions. Assuming that the number of components is given and that each mixture component has independent marginal distributions, we propose a nonparametric method to estimate the component distributions. The basic idea is to convert the estimation of component density functions to a problem of estimating the coordinates of the component density functions with ...
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作者：Banerjee, Trambak; Mukherjee, Gourab; Dutta, Shantanu; Ghosh, Pulak
作者单位：University of Southern California; University of Southern California; Indian Institute of Management (IIM System); Indian Institute of Management Bangalore
摘要：We develop a constrained extremely zero inflated joint (CEZIJ) modeling framework for simultaneously analyzing player activity, engagement, and dropouts (churns) in app-based mobile freemium games. Our proposed framework addresses the complex interdependencies between a player's decision to use a freemium product, the extent of her direct and indirect engagement with the product and her decision to permanently drop its usage. CEZIJ extends the existing class of joint models for longitudinal an...
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作者：Yu, Guan; Yin, Liang; Lu, Shu; Liu, Yufeng
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：With the abundance of large data, sparse penalized regression techniques are commonly used in data analysis due to the advantage of simultaneous variable selection and estimation. A number of convex as well as nonconvex penalties have been proposed in the literature to achieve sparse estimates. Despite intense work in this area, how to perform valid inference for sparse penalized regression with a general penalty remains to be an active research problem. In this article, by making use of state...
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作者：Huling, Jared D.; Smith, Maureen A.; Chen, Guanhua
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Health care payments are an important component of health care utilization and are thus a major focus in health services and health policy applications. However, payment outcomes are semicontinuous in that over a given period of time some patients incur no payments and some patients incur large costs. Individualized treatment rules (ITRs) are a major part of the push for tailoring treatments and interventions to patients, yet there is a little work focused on estimating ITRs from semicontinuou...
