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作者：Rashid, Naim U.; Sun, Wei; Ibrahim, Joseph G.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; Fred Hutchinson Cancer Center
摘要：Sequencing techniques have been widely used to assess gene expression (i.e., RNA-seq) or the presence of epigenetic features (e.g., DNase-seq to identify open chromatin regions). In contrast to traditional microarray platforms, sequencing data are typically summarized in the form of discrete counts, and they are able to delineate allele-specific signals, which are not available from microarrays. The presence of epigenetic features are often associated with gene expression, both of which have b...
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作者：Zhai, Yongliang; Bouchard-Cote, Alexandre
作者单位：University of British Columbia
摘要：We introduce a new inference method to estimate evolutionary distances for any two populations to their most recent common ancestral population using single-nucleotide polymorphism allele frequencies. Our model takes fixation into consideration, making it nonreversible, and guarantees that the distribution of reconstructed ancestral frequencies is contained on the interval [0, 1]. To scale this method to large numbers of populations, we introduce the asymmetric neighbor joining algorithm, an e...
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作者：Chang, Won; Haran, Murali; Applegate, Patrick; Pollard, David
作者单位：University System of Ohio; University of Cincinnati; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Human-induced climate change may cause significant ice volume loss from the West Antarctic Ice Sheet (WAIS). Projections of ice volume change from ice sheet models and corresponding future sea-level rise have large uncertainties due to poorly constrained input parameters. In most future applications to date, model calibration has utilized only modern or recent (decadal) observations, leaving input parameters that control the long-term behavior of WAIS largely unconstrained. Many paleo-observat...
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作者：Lin, Ruitao; Yin, Guosheng
作者单位：University of Hong Kong
摘要：Phase I drug-combination trials are becoming commonplace in oncology. Most of the current dose-finding designs aim to quantify the toxicity probability space using certain prespecified yet complicated models. These models need to characterize not only each individual drug's toxicity profile, but also their interaction effects, which often leads to multi-parameter models. We propose a novel Bayesian adaptive design for drug-combination trials based on a robust dimension-reduction method. We con...
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作者：Admiraal, Ryan; Handcock, Mark S.
作者单位：Murdoch University; University of California System; University of California Los Angeles
摘要：Network-based models for sexually transmitted disease transmission rely on initial partnership networks incorporating structures that may be related to risk of infection. In particular, initial networks should reflect the level of concurrency and attribute-based selective mixing observed in the population of interest. We consider momentary degree distributions as measures of concurrency and propensities for people of certain types to form partnerships with each other as a measure of attribute-...
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作者：Thibaud, Emeric; Aalto, Juha; Cooley, Daniel S.; Davison, Anthony C.; Heikkinen, Juha
作者单位：Colorado State University System; Colorado State University Fort Collins; Finnish Meteorological Institute; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Natural Resources Institute Finland (Luke)
摘要：The Brown-Resnick max-stable process has proven to be well suited for modeling extremes of complex environmental processes, but in many applications its likelihood function is intractable and inference must be based on a composite likelihood, thereby preventing the use of classical Bayesian techniques. In this paper we exploit a case in which the full likelihood of a Brown-Resnick process can be calculated, using componentwise maxima and their partitions in terms of individual events, and we p...
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作者：Ji, Pengsheng; Jin, Jiashun
作者单位：University System of Georgia; University of Georgia; Carnegie Mellon University
摘要：We have collected and cleaned two network data sets: Coauthorship and Citation networks for statisticians. The data sets are based on all research papers published in four of the top journals in statistics from 2003 to the first half of 2012. We analyze the data sets from many different perspectives, focusing on (a) productivity, patterns and trends, (b) centrality and (c) community structures. For (a), we find that over the 10-year period, both the average number of papers per author and the ...
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作者：Chen, Kun; Hoffman, Eric A.; Seetharaman, Indu; Jiao, Feiran; Lin, Ching-Long; Chan, Kung-Sik
作者单位：University of Connecticut; University of Iowa; Kansas State University; University of Iowa; University of Iowa
摘要：The human lung airway is a complex inverted tree-like structure. Detailed airway measurements can be extracted from MDCT-scanned lung images, such as segmental wall thickness, airway diameter, parent-child branch angles, etc. The wealth of lung airway data provides a unique opportunity for advancing our understanding of the fundamental structure-function relationships within the lung. An important problem is to construct and identify important lung airway features in normal subjects and connec...
