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作者：Gu, Mengyang; Berger, James O.
作者单位：Duke University; King Abdulaziz University
摘要：We consider the problem of emulating (approximating) computer models (simulators) that produce massive output. The specific simulator we study is a computer model of volcanic pyroclastic flow, a single run of which produces up to 10(9) outputs over a space-time grid of coordinates. An emulator (essentially a statistical model of the simulator-we use a Gaussian Process) that is computationally suitable for such massive output is developed and studied from practical and theoretical perspectives....
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作者：Liu, Yang; Zidek, James V.; Trites, Andrew W.; Battaile, Brian C.
作者单位：University of British Columbia; University of British Columbia
摘要：Bayesian Melding (BM) and downscaling are two Bayesian approaches commonly used to combine data from different sources for statistical inference. We extend these two approaches to combine accurate but sparse direct observations with another set of high-resolution but biased calculated observations. We use our methods to estimate the path of a moving or evolving object and apply them in a case study of tracking northern fur seals. To make the BM approach computationally feasible for high-dimens...
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作者：Inacio de Carvalho, Vanda; de Carvalho, Miguel; Alonzo, Todd A.; Gonzalez-Manteiga, Wenceslao
作者单位：Pontificia Universidad Catolica de Chile; University of Southern California; Universidade de Santiago de Compostela
摘要：Due to recent advances in technology, medical diagnosis data are becoming increasingly complex and, nowadays, applications where measurements are curves or images are ubiquitous. Motivated by the need of modeling a functional covariate on a metabolic syndrome case study, we develop a nonparametric functional regression model for the area under the specificity receiver operating characteristic curve. This partial area is a meaningful summary measure of diagnostic accuracy for cases in which mis...
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作者：Chekouo, Thierry; Stingo, Francesco C.; Guindani, Michele; Do, Kim-Anh
作者单位：University of Minnesota System; University of Minnesota Duluth; University of Minnesota Twin Cities; University of Minnesota Hospital; University of Florence; University of California System; University of California Irvine; University of Texas System; UTMD Anderson Cancer Center
摘要：Imaging genetics has rapidly emerged as a promising approach for investigating the genetic determinants of brain mechanisms that underlie an individual's behavior or psychiatric condition. In particular, for early detection and targeted treatment of schizophrenia, it is of high clinical relevance to identify genetic variants and imaging-based biomarkers that can be used as diagnostic markers, in addition to commonly used symptom-based assessments. By combining single-nucleotide polymorphism (S...
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作者：Bartlett, Thomas E.; Zaikin, Alexey
作者单位：University of London; University College London; University of London; University College London
摘要：In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer. DNA methylation is a gene-regulatory pattern, and hence provides a means by which to assess genomic regulatory interactions. Network models are a natural way to represent and analyse groups of such ...
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作者：Gladish, Daniel W.; Kuhnert, Petra M.; Pagendam, Daniel E.; Wikle, Christopher K.; Bartley, Rebecca; Searle, Ross D.; Ellis, Robin J.; Dougall, Cameron; Turner, Ryan D. R.; Lewis, Stephen E.; Bainbridge, Zoe T.; Brodie, Jon E.
作者单位：Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of Missouri System; University of Missouri Columbia; James Cook University
摘要：Soil erosion and sediment transport into waterways and the ocean can adversely affect water clarity, leading to the deterioration of marine ecosystems such as the iconic Great Barrier Reef (GBR) in Australia. Quantifying a sediment load and its associated uncertainty is an important task in delineating how changes in management practices can contribute to improvements in water quality, and therefore continued sustainability of the GBR. However, monitoring data are spatially (and often temporal...
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作者：Wong, Raymond K. W.; Lee, Thomas C. M.; Paul, Debashis; Peng, Jie
作者单位：Iowa State University; University of California System; University of California Davis
摘要：Diffusion magnetic resonance imaging is an imaging technology designed to probe anatomical architectures of biological samples in an in vivo and noninvasive manner through measuring water diffusion. The contribution of this paper is threefold. First, it proposes a new method to identify and estimate multiple diffusion directions within a voxel through a new and identifiable parametrization of the widely used multi-tensor model. Unlike many existing methods, this method focuses on the estimatio...
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作者：Arbel, Julyan; Mengersen, Kerrie; Rousseau, Judith
作者单位：Collegio Carlo Alberto; Bocconi University; Queensland University of Technology (QUT); Universite PSL; Universite Paris-Dauphine; Institut Polytechnique de Paris; ENSAE Paris
摘要：We introduce a dependent Bayesian nonparametric model for the probabilistic modeling of membership of subgroups in a community based on partially replicated data. The focus here is on species-by-site data, that is, community data where observations at different sites are classified in distinct species. Our aim is to study the impact of additional covariates, for instance, environmental variables, on the data structure, and in particular on the community diversity. To this end, we introduce dep...
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作者：Shang, Han Lin
作者单位：Australian National University
摘要：A multilevel functional data method is adapted for forecasting age-specific mortality for two or more populations in developed countries with high-quality vital registration systems. It uses multilevel functional principal component analysis of aggregate and population-specific data to extract the common trend and population-specific residual trend among populations. If the forecasts of population-specific residual trends do not show a long-term trend, then convergence in forecasts may be achi...
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作者：Lee, Duncan; Lawson, Andrew
作者单位：University of Glasgow; Medical University of South Carolina
摘要：Maternal smoking is well known to adversely affect birth outcomes, and there is considerable spatial variation in the rates of maternal smoking in the city of Glasgow, Scotland. This spatial variation is a partial driver of health inequalities between rich and poor communities, and it is of interest to determine the extent to which these inequalities have changed over time. Therefore in this paper we develop a Bayesian hierarchical model for estimating the spatio-temporal pattern in smoking in...
