3期

最新文章

• DIRICHLET-TREE MULTINOMIAL MIXTURES FOR CLUSTERING MICROBIOME COMPOSITIONS AI翻译
  作者：Mao, Jialiang; Ma, Li
  作者单位：Duke University
  摘要：Studying the human microbiome has gained substantial interest in recent years, and a common task in the analysis of these data is to cluster microbiome compositions into subtypes. This subdivision of samples into subgroups serves as an intermediary step in achieving personalized diagnosis and treatment. In applying existing clustering methods to modern microbiome studies, including the American Gut Project (AGP) data, we found that this seemingly standard task, however, is very challenging in ...
• ESTIMATION OF THE MARGINAL EFFECT OF ANTIDEPRESSANTS ON BODY MASS INDEX UNDER CONFOUNDING AND ENDOGENOUS COVARIATE-DRIVEN MONITORING TIMES AI翻译
  作者：Coulombe, Janie; Moodie, Erica E. M.; Platt, Robert W.; Renoux, Christel
  作者单位：McGill University
  摘要：In studying the marginal effect of antidepressants on body mass index using electronic health records data, we face several challenges. Patients' characteristics can affect the exposure (confounding) as well as the timing of routine visits (measurement process), and those characteristics may be altered following a visit which can create dependencies between the monitoring and body mass index when viewed as a stochastic or random processes in time. This may result in a form of selection bias th...
• SEMIPARAMETRIC POINT PROCESS MODELING OF BLINKING ARTIFACTS IN PALM AI翻译
  作者：Jensen, Louis G.; Williamson, David J.; Hahn, Ute
  作者单位：Aarhus University; University of London; King's College London
  摘要：Photoactivated localization microscopy (PALM) is a powerful imaging technique for characterization of protein organization in biological cells. Due to the stochastic blinking of fluorescent probes and camera discretization effects, each protein gives rise to a cluster of artificial observations. These blinking artifacts are an obstacle for quantitative analysis of PALM data, and tools for their correction are in high demand. We develop the independent blinking cluster point process (IBCpp) fam...
• MEASUREMENT ERROR CORRECTION IN PARTICLE TRACKING MICRORHEOLOGY AI翻译
  作者：Ling, Yun; Lysy, Martin; Seim, Ian; Newby, Jay; Hill, David B.; Cribb, Jeremy; Forest, M. Gregory
  作者单位：University of Waterloo; University of North Carolina; University of North Carolina Chapel Hill; University of Alberta; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
  摘要：In diverse biological applications, single-particle tracking (SPT) of passive microscopic species has become the experimental measurement of choice, when either the materials are of limited volume or so soft as to deform uncontrollably when manipulated by traditional instruments. In a wide range of SPT experiments, a ubiquitous finding is that of long-range dependence in the particles' motion. This is characterized by a power-law signature in the mean squared displacement (MSD) of particle pos...
• MODEL-BASED DISTANCE EMBEDDING WITH APPLICATIONS TO CHROMOSOMAL CONFORMATION BIOLOGY AI翻译
  作者：Zhang, Yuping; Mao, Disheng; Ouyang, Zhengqing
  作者单位：University of Connecticut; University of Massachusetts System; University of Massachusetts Amherst
  摘要：Recent development of high-throughput biotechnologies, such as Hi-C, have enabled genome-wide measurement of chromosomal conformation. The interaction signals among genomic loci are contaminated with noises. It remains largely unknown how well the underlying chromosomal conformation can be elucidated, based on massive and noisy measurements. We propose a new model-based distance embedding (MDE) framework, to reveal spatial organizations of chromosomes. The proposed framework is a general metho...
• MEASURING PERFORMANCE FOR END-OF-LIFE CARE AI翻译
  作者：Haneuse, Sebastien; Schrag, Deborah; Dominici, Francesca; Normand, Sharon-Lise; Lee, Kyu Ha
  作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School
  摘要：Although not without controversy, readmission is entrenched as a hospital quality metric with statistical analyses generally based on fitting a logistic-Normal generalized linear mixed model. Such analyses, however, ignore death as a competing risk, although doing so for clinical conditions with high mortality can have profound effects; a hospital's seemingly good performance for readmission may be an artifact of it having poor performance for mortality. In this paper we propose novel multivar...
• ESTIMATING MODE EFFECTS FROM A SEQUENTIAL MIXED-MODE EXPERIMENT USING STRUCTURAL MOMENT MODELS AI翻译
  作者：Clarke, Paul S.; Bao, Yanchun
  作者单位：University of Essex; University of Essex
  摘要：Until recently, the survey mode of the household panel study Understanding Society was mainly face-to-face interview, but it has now adopted a mixed-mode design where individuals can self-complete the questionnaire via the web. As mode is known to affect survey data, a randomized mixedmode experiment was implemented during the first year of the two-yearWave 8 fieldwork period to assess the impact of this change. The experiment involved a sequential design that permits the identification of mod...
• MODELING ANIMAL MOVEMENT WITH DIRECTIONAL PERSISTENCE AND ATTRACTIVE POINTS AI翻译
  作者：Mastrantonio, Gianluca
  作者单位：Polytechnic University of Turin
  摘要：GPS technology is currently easily accessible to researchers, and many animal movement data sets are available. Two of the main features that a model which describes an animal's path can possess are directional persistence and attraction to a point in space. In this work, we propose a new approach that can have both characteristics. Our proposal is a hidden Markov model with a new emission distribution. The emission distribution models the two aforementioned characteristics, while the latent s...
• MATRIX COMPLETION METHODS FOR THE TOTAL ELECTRON CONTENT VIDEO RECONSTRUCTION AI翻译
  作者：Sun, Hu; Hua, Zhijun; Ren, Jiaen; Zou, Shasha; Sun, Yuekai; Chen, Yang
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：The total electron content (TEC) maps can be used to estimate the signal delay of GPS due to the ionospheric electron content between a receiver and satellite. This delay can result in GPS positioning error. Thus, it is important to monitor the TEC maps. The observed TEC maps have big patches of missingness in the ocean and scattered small areas of missingness on the land. In this paper we propose several extensions of existing matrix completion algorithms to achieve TEC map reconstruction, ac...
• CO-CLUSTERING OF MULTIVARIATE FUNCTIONAL DATA FOR THE ANALYSIS OF AIR POLLUTION IN THE SOUTH OF FRANCE AI翻译
  作者：Bouveyron, Charles; Jacques, Julien; Schmutz, Amandine; Simoes, Fanny; Bottini, Silvia
  作者单位：Universite Cote d'Azur; Inria; Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur
  摘要：Nowadays, air pollution is a major threat for public health with clear relationships with many diseases, especially cardiovascular ones. The spatiotemporal study of pollution is of great interest for governments and local authorities when deciding for public alerts or new city policies against pollution increase. The aim of this work is to study spatiotemporal profiles of environmental data collected in the south of France (Region Sud) by the public agency AtmoSud. The idea is to better unders...