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作者：Karanfil, Oezge; Barlas, Yaman
作者单位：Simon Fraser University; Bogazici University
摘要：A dynamic model is built to study the water regulation of human body and related disorders, focusing on the fundamental feedback mechanisms involved in their normal and abnormal physiology. The simulation model is extended to include therapeutic interventions related to the most common body fluid disorder, namely, water intoxication/hyponatremia. The modeling approach is based on system dynamics methodology. Comparisons with experimental and field data show that the model adequately reproduces...
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作者：Chick, Stephen E.; Mamani, Hamed; Simchi-Levi, David
作者单位：INSEAD Business School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Annual influenza outbreaks incur great expenses in both human and monetary terms, and billions of dollars are being allocated for influenza pandemic preparedness in an attempt to avert even greater potential losses. Vaccination is a primary weapon for fighting influenza outbreaks. The influenza vaccine supply chain has characteristics that resemble the newsvendor problem but possesses several characteristics that distinguish it from many other supply chains. Differences include a nonlinear val...
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作者：Patrick, Jonathan; Puterman, Martin L.; Queyranne, Maurice
作者单位：University of Ottawa; University of British Columbia
摘要：We present a method to dynamically schedule patients with different priorities to a diagnostic facility in a public health-care setting. Rather than maximizing revenue, the challenge facing the resource manager is to dynamically allocate available capacity to incoming demand to achieve wait-time targets in a cost-effective manner. We model the scheduling process as a Markov decision process. Because the state space is too large for a direct solution, we solve the equivalent linear program thro...
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作者：Green, Linda V.; Savin, Sergei
作者单位：Columbia University
摘要：Many primary care offices and other medical practices regularly experience long backlogs for appointments. These backlogs are exacerbated by a significant level of last-minute cancellations or no-shows, which have the effect of wasting capacity. In this paper, we conceptualize such an appointment system as a single-server queueing system in which customers who are about to enter service have a state-dependent probability of not being served and may rejoin the queue. We derive stationary distri...
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作者：Crama, Pascale; De Reyck, Bert; Degraeve, Zeger
作者单位：Singapore Management University; University of London; University College London; University of London; London Business School
摘要：We study how innovators can optimally design licensing contracts when there is incomplete information on the licensee's valuation of the innovation, and limited control over the licensee's development efforts. A licensing contract typically contains an up-front payment, milestone payments at successful completion of a project phase, and royalties on sales. We use principal-agent models to formulate the licensor's contracting problem, and we find that under adverse selection, the optimal contra...
