Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection

• 成果类型: Article
• 署名作者: Chen, Gongwen; Jun, Ji Hyung; Wijshake, Tobias; Kwarteng, Edward O.; Li, Yunyang; Yuan, Minwei; Rose, Joseph; Li, Shan; Cobb, Sarah; Serpa, Willow; Folger, Brayden; Li, Yafeng; Li, Li; Chen, Weina; Collins, James J.; Wang, Jipeng; Agathocleous, Michali
• 署名单位: Fudan University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Inner Mongolia University; University of Texas System; University of Texas Southwestern Medical Center; Texas Tech University System; Texas Tech University; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2517730122
• 发表日期: 2025-12-30
• 页码: e2517730122
• 关键词: ascorbate; parasitology; host-microbe interactions; vitamins; schistosomes; SCHISTOSOMA-MANSONI; ASCORBIC-ACID; GRANULOMA-FORMATION; stem-cells; ANTIOXIDANT; transporter; mortality; markers; mice

摘要

The ability to synthesize essential molecules is sometimes lost in evolution. A classic example is ascorbate (vitamin C), which is synthesized in most animals by L-gulonolactone oxidase (GULO), an enzyme lost multiple independent times in animal evolution. This event is thought to be evolutionarily neutral; however, GULO-deficient animals including humans need to obtain ascorbate from their diet and are prone to ascorbate deficiency and scurvy. We therefore hypothesized that this disadvantage of GULO loss is offset by physiological benefits. Here, we show that ascorbate deficiency benefits mice infected with schistosome parasites, which cause schistosomiasis, a debilitating parasitic disease that afflicts 250 million people. Schistosoma mansoni worms required host ascorbate to produce eggs in vivo. Consequently, ascorbate-deficient mice were protected from schistosomiasis pathologies and transmission. Intermittent ascorbate deficiency protected Gulo-deficient mice from both scurvy and schistosomiasis mortality. The effects of ascorbate on schistosome reproduction were mediated by ascorbate-dependent histone demethylation which promoted vitellocyte development in female schistosomes. We propose that vitamin deficiencies are not always detrimental but can protect animals from pathogens which need to obtain vitamins from their host.