Parallel systems for social and spatial cognition reaching the cortical apex

• 成果类型: Article
• 署名作者: Deen, Ben; Freiwald, Winrich A.
• 署名单位: Tulane University; Tulane University; Rockefeller University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2520067122
• 发表日期: 2025-11-04
• 页码: e2520067122
• 关键词: social cognition; spatial cognition; default mode network; Theory of mind; long-term memory; distributed networks; default-mode; PARAHIPPOCAMPAL CORTEX; macaque monkey; memory; ORGANIZATION; temporopolar; RECOGNITION; face; specialization

摘要

How are systems supporting high-level cognition organized in the human brain? We hypothesize that cognitive processes involved in understanding people and places are implemented by distinct neural systems with parallel anatomical organization. We test this hypothesis using precision neuroimaging of individual human brains on diverse tasks involving perception and cognition in the domains of familiar people, places, and objects. We find that thinking about people and places elicits responses in distinct areas of high-level association cortex within the default mode network, spanning the frontal, parietal, and temporal lobes. Person-and place-preferring brain regions are systematically spatially adjacent across cortical zones. These areas have strongly domain-specific response profiles across visual, semantic, and episodic tasks and are specifically functionally connected to other parts of association cortex with like domain preference. Social and spatial networks remain anatomically separated at the apex of a unimodal-to-transmodal gradient across cortex and include regions with anatomical connections to the hippocampal formation. These results demonstrate the existence of parallel, domain-specific networks reaching the cortical apex.