Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain

• 成果类型: Article
• 署名作者: Jia, Longzhong; Li, Xiaohan; Yan, Yiming; Xu, Linhe; Guo, Jianbin; Wang, Weichao; Zhang, Weirong; Li, Lianyan; Shang, Borui; Zhang, Yiwei; Dang, Yashan; Zeng, Yuyan; Liao, Zhiyan; Liang, Ruijuan; Gu, Li; He, Chenyi; Long, Zhen; Hou, Hanqing; Zhou, Yuhan; Yan, Mingchao; Huang, Wei; Zhu, Lan; Mi, Da
• 署名单位: Tsinghua University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Shandong First Medical University & Shandong Academy of Medical Sciences; Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adw1803
• 发表日期: 2026-01-15
• 页码: eadw1803
• 关键词: evolution; diversity; neocortex; interneurons; progenitors; origins; lineage

摘要

The number and diversity of inhibitory neurons (INs) increased substantially during mammalian brain evolution. However, the generative mechanisms of the vast repertoire of human INs remain elusive. We performed spatial and single-cell transcriptomics of human medial ganglionic eminence (hMGE), a pivotal source of cortical and subpallial INs, and built the trajectories of hMGE-derived cells during brain development. We identified spatiotemporally and molecularly segregated progenitor cell populations fated to produce distinct IN types. We uncovered an evolutionarily distinct progenitor cell type in the hMGE subventricular zone that maintained the production of INs and glial cells throughout human brain development. Our findings reveal evolutionarily distinct features of IN generation and shed light on the distinct mechanisms underlying human brain development.