Genomes of Poaceae relatives reveal key metabolic innovations preceding the evolution of grasses

• 成果类型: Article
• 署名作者: Takeda-Kimura, Yuri; Moore, Bethany; Holden, Samuel; Morris, Jae S.; Deb, Sontosh K.; Sanders, Carly; El-Azaz, Jorge; Barrett, Matt; Lorence, David; de Oliveira, Marcos V. V.; Havranek, Wynne; Grimwood, Jane; Williams, Melissa; Boston, Lori Beth; Jenkins, Jerry; Plott, Christopher; Shu, Shengqiang; Barry, Kerrie; Goodstein, David M.; Schmutz, Jeremy; Jez, Joseph M.; Moscou, Matthew J.; McKain, Michael R.; Leebens-Mack, James H.; Maeda, Hiroshi A.
• 署名单位: University of Wisconsin System; University of Wisconsin Madison; Yamagata University; University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Washington University (WUSTL); University of Alabama System; University of Alabama Tuscaloosa; James Cook University; HudsonAlpha Institute for Biotechnology; United States Department of Energy (DOE); Joint Genome Institute - JGI; United States Department of Agriculture (USDA); University of Alabama System; University of Alabama Tuscaloosa; University System of Georgia; University of Georgia
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adv0443
• 发表日期: 2026-08-20
• 页码: eadv0443
• 关键词: ADP-GLUCOSE PYROPHOSPHORYLASE; STARCH BIOSYNTHETIC-PATHWAY; PHENYLALANINE AMMONIA-LYASE; ACETYL-COA CARBOXYLASE; substrate-specificity; draft sequence; gene; alignment; transcriptome; polyploidy

摘要

The grass family (Poaceae) has immense economic and ecological importance and exhibits distinctive metabolic traits, including dual starch and lignin biosynthetic pathways. We sequenced the genomes of Pharus, Joinvillea, Ecdeiocolea, and Typha species to investigate when and how these metabolic innovations evolved relative to the origin of the grass family. The rho whole-genome duplication (rho WGD) within the lineage that led to the last common ancestor of all grasses contributed to the gene family expansions underlying cytosolic starch biosynthesis, whereas an earlier tandem duplication of phenylalanine ammonia lyase (PAL) gave rise to phenylalanine/tyrosine ammonia lyase (PTAL), which is responsible for the dual lignin biosynthesis. Integrated biochemical, functional, and structural studies, guided by phylogenomic analyses, further revealed the molecular basis of key metabolic innovations predating the evolution of grasses.