Clinically ready magnetic microrobots for targeted therapies

• 成果类型: Article
• 署名作者: Landers, Fabian C.; Hertle, Lukas; Pustovalov, Vitaly; Sivakumaran, Derick; Oral, Cagatay M.; Brinkmann, Oliver; Meiners, Kirstin; Theiler, Pascal; Gantenbein, Valentin; Veciana, Andrea; Mattmann, Michael; Riss, Silas; Gervasoni, Simone; Chautems, Christophe; Ye, Hao; Sevim, Semih; Flouris, Andreas D.; Puigmarti-Luis, Josep; Mayor, Tiago Sotto; Alves, Pedro; Luhmann, Tessa; Chen, Xiangzhong; Ochsenbein, Nicole; Moehrlen, Ueli; Schubert, Tilman; Kulcsar, Zsolt; Gruber, Philipp; Weisskopf, Miriam; Boehler, Quentin; Pane, Salvador; Nelson, Bradley J.
• 署名单位: Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Wurzburg; University of Thessaly; University of Barcelona; ICREA; Universidade do Porto; Universidade do Porto; Fudan University; Fudan University; University of Zurich; University Zurich Hospital; University of Zurich; University Children's Hospital Zurich; University of Zurich; University Zurich Hospital; Kantonsspital Aarau AG (KSA); University of Zurich; University Zurich Hospital
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adx1708
• 发表日期: 2025-11-13
• 页码: 710-715
• 关键词: CEREBRAL-ARTERY; blood-flow; contrast; SYSTEM; core

摘要

Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery platform capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, offering a promising solution for precise targeted drug delivery.