Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors

• 成果类型: Article
• 署名作者: Mironova, Yevgeniya A.; Dang, Brendan; Heo, Dongeun; Xu, Yu Kang T.; Hsu, Angela Yu-Huey; von Bernhardi, Jaime Eugenin; Molina-Castro, Gian Carlo; Kim, Anya A.; Lin, Jing-Ping; Reich, Daniel S.; Bergles, Dwight E.
• 署名单位: Johns Hopkins University; Johns Hopkins Medicine; Washington University (WUSTL); Oregon Health & Science University; Johns Hopkins University; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Harvard University; Howard Hughes Medical Institute; Harvard Medical School
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adu2896
• 发表日期: 2026-01-22
• 页码: eadu2896
• 关键词: PDGF ALPHA-RECEPTOR; chondroitin sulfate; multiple-sclerosis; molecular-cloning; PRECURSOR CELLS; PREMYELINATING OLIGODENDROCYTES; DEMYELINATED AXONS; NG2 PROTEOGLYCAN; white-matter; remyelination

摘要

Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (OPCs) promotes myelin plasticity and repair in the adult brain. Here, we performed genetic interrogation and in vivo analysis of OPCs in the mouse brain to determine their differentiation dynamics. Our results show that OPCs attempt to differentiate throughout the adult central nervous system with spatial and temporal regularity. The differentiation rate was not influenced by myelin demand or oligodendrocyte loss and declined with age and in response to acute inflammation. The results suggest that OPC differentiation is governed primarily by constitutive processes and might be negatively influenced by aging and inflammation.