SEQUENTIAL-ANALYSIS OF COMPARATIVE CLINICAL-TRIALS
成果类型：
Article
署名作者：
BEGG, CB; MEHTA, CR
署名单位：
Harvard University; Harvard T.H. Chan School of Public Health; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.1093/biomet/66.1.97
发表日期：
1979
页码：
97103
关键词：
摘要：
An adaptive procedure is proposed for a comparative clinical trial of 2 treatments in which the response variable has a normal distribution. Patients are assumed to arrive in pairs, and at each stage, after each pair has been treated, a decision is made either to continue to the next stage, or to suspend randomization and to assign patients to the best treatment. This leads to stopping rules which are tabulated for a variety of patient horizons. In general, trials will be relatively short, and the patient horizon is less influential in determining trial duration than was previously suggested.