DESIGN AND ANALYSIS OF GROUP SEQUENTIAL-TESTS BASED ON THE TYPE-I ERROR SPENDING RATE-FUNCTION
成果类型：
Article
署名作者：
KIM, K; DEMETS, DL
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.1093/biomet/74.1.149
发表日期：
1987
页码：
149154
关键词：
摘要：
Lan and DeMets (1983) devised a method for constructing discrete group sequential boundaries by using the type I error spending rate function. It is extended so as to generate asymmetric as well as symmetric two-sided boundaries for clinical trials. The design aspect of this procedure is explored in terms of the maximum sample size needed to achieve a desired level of power and the expected stopping times under both null and alternative hypotheses. Finally, these properties are employed in search of appropriate type I error spending rate functions for differing situations.