METHODOLOGY FOR CASE-CONTROL STUDIES WITH PREVALENT CASES
成果类型：
Note
署名作者：
BEGG, CB; GRAY, RJ
署名单位：
Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.1093/biomet/74.1.191
发表日期：
1987
页码：
191195
关键词：
摘要：
A method is developed for the analysis of case-control studies with prevalent cases. The method permits adjustments for potential bias induced by association of the exposure of interest and/or covariates with survival. The only additional information required is the time since diagnosis of each prevalent case. The method employs an accelerated life model, the parameters of which are estiamted using quasi-likelihood techniques. In this way, no assumptions are required about the random component of the survival distribution. The method is shown to be typically less efficient than a study of similar size using incident cases. However, the ease of obtaining prevalent subjects offers considerable potential for assembling much larger samples of prevalent cases, leading to much more efficient studies overall.
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