EXACT 2-SAMPLE PERMUTATION TESTS BASED ON THE RANDOMIZED PLAY-THE-WINNER RULE
成果类型：
Article
署名作者：
WEI, LJ
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
DOI：
10.2307/2336615
发表日期：
1988
页码：
603606
关键词：
摘要：
In comparing two treatments in a clinical trial, the randomized play-the-winner rule tends to assign more study subjects to the better treatment. It is applicable when patients have delayed responses to treatments. It is not deterministic and is less vulnerable to experimental bias than other adaptive designs. In this paper, an efficient algorithm is provided to construct exact permutation tests for testing the equality of the two treatments with the randomized play-the winner rule. The test procedure is illustrated with a real-life example. The example shows that the design used in the trial should not be ignored in the analysis.