EFFICIENCY ROBUST SCORE TESTS FOR RODENT TUMORIGENICITY EXPERIMENTS
成果类型：
Article
署名作者：
BURNETT, R; KREWSKI, D; BLEUER, S
刊物名称：
BIOMETRIKA
ISSN/ISSBN：
0006-3444
发表日期：
1989
页码：
317324
关键词：
摘要：
The standard statistical test for assessing adverse effects in rodent tumourigenicity experiments is based on a time-adjusted analysis of lethal and incidental tumours. This test is shown to arise as the sum of two score statistics for fatal and incidental lesions respectively, the former optimal against extreme value hazard alternatives and the latter optimal against logistic prevalence alternatives in terms of asymptotic relative efficiency in the Pitman sense. An efficiency robust test is developed which retains near full efficiency in the extreme value/logistic situation as well as in other situations where the standard test may be only 70% efficient.