THE USE OF THE ANGULAR TRANSFORMATION IN BIOLOGICAL ASSAYS
成果类型：
Article
署名作者：
KNUDSEN, LF; CURTIS, JM
刊物名称：
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
ISSN/ISSBN：
0162-1459
DOI：
10.2307/2280657
发表日期：
1947
页码：
282-296
关键词：
摘要：
For biological assays designed to compare a sample of unknown potency with a standard in terms of % response, the angular transformation is advocated as giving essentially the same results as the probit transformation but requiring much less computation. Several modifications of assay design permit further simplification. By using the same number of animals for each dose, only 2 dosage levels each of standard and unknown, and a constant ratio of high dose to low dose, results may be so simplified that a graph and nomograph suffice for computing potency and estimated standard error of assay.