BAGS: A Bayesian Adaptive Group Sequential Trial Design With Subgroup-Specific Survival Comparisons

• 成果类型: Article
• 署名作者: Lin, Ruitao; Thall, Peter F.; Yuan, Ying
• 署名单位: University of Texas System; UTMD Anderson Cancer Center
• 刊物名称: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
• ISSN/ISSBN: 0162-1459
• DOI: 10.1080/01621459.2020.1837142
• 发表日期: 2020
• 页码: 322-334
• 关键词: basket trial; nonproportional hazards; enrichment designs; clinical-trials; Heterogeneity; regression; phase-3; time

摘要

A Bayesian group sequential design is proposed that performs survival comparisons within patient subgroups in randomized trials where treatment-subgroup interactions may be present. A latent subgroup membership variable is assumed to allow the design to adaptively combine homogeneous subgroups, or split heterogeneous subgroups, to improve the procedure's within-subgroup power. If a baseline covariate related to survival is available, the design may incorporate this information to improve subgroup identification while basing the comparative test on the average hazard ratio. General guidelines are provided for calibrating prior hyperparameters and design parameters to control the overall Type I error rate and optimize performance. Simulations show that the design is robust under a wide variety of different scenarios. When two or more subgroups are truly homogeneous but differ from the other subgroups, the proposed method is substantially more powerful than tests that either ignore subgroups or conduct a separate test within each subgroup. for this article are available online.