Robust Management of Motion Uncertainty in Intensity-Modulated Radiation Therapy
成果类型：
Article
署名作者：
Bortfeld, Thomas; Chan, Timothy C. Y.; Trofimov, Alexei; Tsitsiklis, John N.
署名单位：
Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
刊物名称：
OPERATIONS RESEARCH
ISSN/ISSBN：
0030-364X
DOI：
10.1287/opre.1070.0484
发表日期：
2008
页码：
1461-1473
关键词：
摘要：
Radiation therapy is subject to uncertainties that need to be accounted for when determining a suitable treatment plan for a cancer patient. For lung and liver tumors, the presence of breathing motion during treatment is a challenge to the effective and reliable delivery of the radiation. In this paper, we build a model of motion uncertainty using probability density functions that describe breathing motion, and provide a robust formulation of the problem of optimizing intensity-modulated radiation therapy. We populate our model with real patient data and measure the robustness of the resulting solutions on a clinical lung example. Our robust framework generalizes current mathematical programming formulations that account for motion, and gives insight into the trade-off between sparing the healthy tissues and ensuring that the tumor receives sufficient dose. For comparison, we also compute solutions to a nominal (no uncertainty) and margin (worst-case) formulation. In our experiments, we found that the nominal solution typically underdosed the tumor in the unacceptable range of 6% to 11%, whereas the robust solution underdosed by only 1% to 2% in the worst case. In addition, the robust solution reduced the total dose delivered to the main organ-at-risk (the left lung) by roughly 11% on average, as compared to the margin solution.