The Effects of Pharmaceutical Marketing and Promotion on Adverse Drug Events and Regulation

• 成果类型: Article
• 署名作者: David, Guy; Markowitz, Sara; Richards-Shubik, Seth
• 署名单位: University of Pennsylvania; Emory University; Carnegie Mellon University
• 刊物名称: AMERICAN ECONOMIC JOURNAL-ECONOMIC POLICY
• ISSN/ISSBN: 1945-7731
• DOI: 10.1257/pol.2.4.1
• 发表日期: 2010
• 页码: 1-25
• 关键词: patients requests; approval times; physicians; industry; safety; POLICY

摘要

This paper analyzes the relationship between postmarketing promotional activity and reporting of adverse drug reactions (ADRs) by modeling the interaction between a regulator (the FDA) and a pharmaceutical firm. Promotion-driven market expansions enhance profitability yet may involve the risk of inappropriate drug prescriptions, leading to regulatory actions against the firm. We empirically test the relationship between drug promotion and reporting of ADRs using an innovative combination of commercial data on pharmaceutical promotion and FDA data on regulatory interventions and ADRs. We provide some evidence that increased levels of promotion and advertising lead to increased reporting of ADRs for certain conditions.