Live magnetic observation of parahydrogen hyperpolarization dynamics

• 成果类型: Article
• 署名作者: Eills, James; Mitchell, Morgan W.; Rius, Irene Marco; Tayler, Michael C. D.
• 署名单位: University of Barcelona; Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); ICREA; Helmholtz Association; Research Center Julich
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15109
• DOI: 10.1073/pnas.2410209121
• 发表日期: 2024-10-22
• 关键词: para-hydrogen; polarization transfer; nuclear spins; field; nmr; ORDER; polarimetry; dnp

摘要

Hyperpolarized nuclear spins in molecules exhibit high magnetization that is unachievable by classical polarization techniques, making them widely used as sensors in physics, chemistry, and medicine. The state of a hyperpolarized material, however, is typically only studied indirectly and with partial destruction of magnetization, due to the nature of conventional detection by resonant-pickup NMR spectroscopy or imaging. Here, we establish atomic magnetometers with sub-pT sensitivity as an alternative modality to detect in real time the complex dynamics of hyperpolarized materials without disturbing or interrupting the magnetogenesis process. As an example of dynamics that are impossible to detect in real time by conventional means, we examine parahydrogen-induced H-1 and C-13 magnetization during adiabatic eigenbasis transformations at mu mu T-field avoided crossings. Continuous but nondestructive magnetometry reveals previously unseen spin dynamics, fidelity limits, and magnetization backaction effects. As a second example, we apply magnetometry to observe the chemical-exchange-driven C-13 hyperpolarization of [1-C-13]-pyruvate-the most important spin tracer for clinical metabolic imaging. The approach can be readily combined with other high-sensitivity magnetometers and is applicable to a broader range of general observation scenarios involving production, transport, and systems interaction of hyperpolarized compounds.