Locus coeruleus integrity is related to an exploitation- based decision- making bias in older adulthood
成果类型：
Article
署名作者：
Turner, Gary R.; Hewan, Patrick; Wearn, Alfie; van Dooren, Roel; Wyatt, Lindsay; Leppert, Ilana R.; Baracchini, Giulia; Hughes, Colleen; Williams, Kayla M.; Sylvain, Elisabeth; Mercier, Jennifer Tremblay -; Poirier, Judes; Villeneuve, Sylvia; Tardif, Christine; Spreng, R. Nathan
署名单位：
York University - Canada; McGill University; Leiden University - Excl LUMC; Leiden University; Leiden University; Leiden University - Excl LUMC; McGill University; McGill University; McGill University; McGill University
刊物名称：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN/ISSBN：
0027-14917
DOI：
10.1073/pnas.2322617121
发表日期：
2024-05-28
关键词：
摘要：
Optimal decision - making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation - bias that emerges in older adulthood would be associated with lower microstructural integrity of the locus coeruleus. Leveraging in vivo histological methods from quantitative MRI - magnetic transfer saturation-we provide evidence that older age is associated with lower locus coeruleus integrity. Critically, we demonstrate that an exploitation bias in older adulthood, assessed with a foraging task, is sensitive and specific to lower locus coeruleus integrity. Because the locus coeruleus is uniquely vulnerable to Alzheimer's disease pathology, our findings suggest that aging, and a presymptomatic trajectory of Alzheimer's related decline, may fundamentally alter decision - making abilities in later life.