A neural pathway for social modulation of spontaneous locomotor activity (SoMo- SLA) in Drosophila

• 成果类型: Article
• 署名作者: Zhao, Huan; Jiang, Xinyu; Ma, Mingze; Xing, Limin; Ji, Xiaoxiao; Pan, Yufeng; Luo, Liqun
• 署名单位: Southeast University - China; Nantong University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11404
• DOI: 10.1073/pnas.2314393121
• 发表日期: 2024-02-27
• 关键词: male courtship; hormonal modulation; pheromone detection; experience; neurons; BEHAVIOR; sleep; LIFE; aggression; activation

摘要

Social enrichment or social isolation affects a range of innate behaviors, such as sex, aggression, and sleep, but whether there is a shared mechanism is not clear. Here, we report a neural mechanism underlying social modulation of spontaneous locomotor activity (SoMo-SLA), an internal- driven behavior indicative of internal states. We find that social enrichment specifically reduces spontaneous locomotor activity in male flies. We identify neuropeptides Diuretic hormone 44 (DH44) and Tachykinin (TK) to be up- and down- regulated by social enrichment and necessary for SoMo-SLA. We further demonstrate a sexually dimorphic neural circuit, in which the male- specific P1 neurons encoding internal states form positive feedback with interneurons coexpressing doublesex (dsx) and Tk to promote locomotion, while P1 neurons also form negative feedback with interneurons coexpressing dsx and DH44 to inhibit locomotion. These two opposing neuromodulatory recurrent circuits represent a potentially common mechanism that underlies the social regulation of multiple innate behaviors.