Human adolescent brain similarity development is different for paralimbic versus neocortical zones

• 成果类型: Article
• 署名作者: Dorfschmidt, Lena; Vasa, Frantisek; White, Simon R.; Romero-Garcia, Rafael; Kitzbichler, Manfred G.; Alexander-Bloch, Aaron; Cieslak, Matthew; Mehta, Kahini; Satterthwaite, Theodore D.; Bethlehem, Richard A. I.; Seidlitz, Jakob; Vertes, Petra E.; Bullmore, Edward T.
• 署名单位: University of Cambridge; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; University of London; King's College London; Consejo Superior de Investigaciones Cientificas (CSIC); CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University of Sevilla; Virgen del Rocio University Hospital; University of Cambridge; University of Cambridge; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Cambridge
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10218
• DOI: 10.1073/pnas.2314074121
• 发表日期: 2024-08-13
• 关键词: morphometric similarity; cerebral-cortex; connectivity; ORGANIZATION; tractography; CONVERGENCE; networks; models

摘要

Adolescent development of human brain structural and functional networks is increasingly recognized as fundamental to emergence of typical and atypical adult cognitive and emotional processes. We analysed multimodal magnetic resonance imaging (MRI) data collected from N similar to 300 healthy adolescents (51%; female; 14 to 26 y) each scanned repeatedly in an accelerated longitudinal design, to provide an analyzable dataset of 469 structural scans and 448 functional MRI scans. We estimated the morphometric similarity between each possible pair of 358 cortical areas on a feature vector comprising six macro- and microstructural MRI metrics, resulting in a morphometric similarity network (MSN) for each scan. Over the course of adolescence, we found that morphometric similarity increased in paralimbic cortical areas, e.g., insula and cingulate cortex, but generally decreased in neocortical areas, and these results were replicated in an independent developmental MRI cohort (N similar to 304). Increasing hubness of paralimbic nodes in MSNs was associated with increased strength of coupling between their morphometric similarity and functional connectivity. Decreasing hubness of neocortical nodes in MSNs was associated with reduced strength of structure-function coupling and increasingly diverse functional connections in the corresponding fMRI networks. Neocortical areas became more structurally differentiated and more functionally integrative in a metabolically expensive process linked to cortical thinning and myelination, whereas paralimbic areas specialized for affective and interoceptive functions became less differentiated, as hypothetically predicted by a developmental transition from periallocortical to proisocortical organization of the cortex. Cytoarchitectonically distinct zones of the human cortex undergo distinct neurodevelopmental programs during typical adolescence.