Representation of a perceptual bias in the prefrontal cortex

• 成果类型: Article
• 署名作者: Serrano-Fernandez, Luis; Beiran, Manuel; Romo, Ranulfo; Parga, Nestor
• 署名单位: Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - UAM - Institut de Fisica Teorica (IFT); Autonomous University of Madrid; Autonomous University of Madrid; Columbia University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9947
• DOI: 10.1073/pnas.2312831121
• 发表日期: 2024-12-05
• 关键词: parametric working-memory; DECISION; INFORMATION; computations; neurons; CODE

摘要

Perception is influenced by sensory stimulation, prior knowledge, and contextual which collectively contribute to the emergence of perceptual biases. However, precise neural mechanisms underlying these biases remain poorly understood. study aims to address this gap by analyzing neural recordings from the prefrontal cortex (PFC) of monkeys performing a vibrotactile frequency discrimination task. findings provide empirical evidence supporting the hypothesis that perceptual biases can be reflected in the neural activity of the PFC. We found that the state-space trajectories of PFC neuronal activity encoded a warped representation of the frequency presented during the task. Remarkably, this distorted representation of frequency aligned with the predictions of its Bayesian estimator. The identification of these neural correlates expands our understanding of the neural basis of perceptual biases and highlights the involvement of the PFC in shaping perceptual experiences. Similar analyses could be employed in other delayed comparison tasks and in various brain regions to explore where and how neural activity reflects perceptual biases during different stages of the trial.