Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals

• 成果类型: Article
• 署名作者: Windred, Daniel P.; Burns, Angus C.; Lane, Jacqueline M.; Olivier, Patrick; Rutter, Martin K.; Saxena, Richa; Phillips, Andrew J. K.; Cain, Sean W.
• 署名单位: Flinders University South Australia; Monash University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Monash University; University of Manchester; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9056
• DOI: 10.1073/pnas.2405924121/-/DCSupplemental
• 发表日期: 2024-10-22
• 关键词: circadian phase; sun exposure; shift work; melatonin; suppression; amplitude; associations; rhythmicity; survival; sunlight

摘要

Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts mortality risk has not been established. We therefore investigated whether personal day and night light, and light patterns that disrupt 62.4 +/- 7.8 y, 57% female) wore light sensors for 1 wk. Day and night light exposures were defined by factor analysis of 24- h light profiles. A computational model of the human circadian pacemaker was applied to model circadian amplitude and phase from light data. Cause- specific mortality was recorded in 3,750 participants across a mean (+/- SD) follow- up period of 8.0 +/- 1.0 y. Individuals with brighter day light had incrementally lower all- cause mortality risk (adjusted- HR ranges: 0.84 to 0.90 [50 to 70th light exposure percentiles], 0.74 to 0.84 [70 to 90th], and 0.66 to 0.83 [90 to 100th]), and those 1.15 to 1.18 [70 to 90th], and 1.21 to 1.34 [90 to 100th]), compared to individuals in or later circadian phase (aHR range: 1.13 to 1.20) had higher all- cause mortality risks. that enhance circadian rhythms may promote cardiometabolic health and longevity.