Low protease activity in B cell follicles promotes retention of intact antigens after immunization

• 成果类型: Article
• 署名作者: Aung, Aereas; Cui, Ang; Maiorino, Laura; Amini, Ava P.; Gregory, Justin R.; Bukenya, Maurice; Zhang, Yiming; Lee, Heya; Cottrell, Christopher A.; Morgan, Duncan M.; Silva, Murillo; Suh, Heikyung; Kirkpatrick, Jesse D.; Amlashi, Parastoo; Remba, Tanaka; Froehle, Leah M.; Xiao, Shuhao; Abraham, Wuhbet; Adams, Josetta; Love, J. Christopher; Huyett, Phillip; Kwon, Douglas S.; Hacohen, Nir; Schief, William R.; Bhatia, Sangeeta N.; Irvine, Darrell J.
• 署名单位: Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University; Microsoft; Massachusetts Institute of Technology (MIT); Scripps Research Institute; Scripps Research Institute; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Ragon Institute; Harvard University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts Eye & Ear Infirmary; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Scripps Research Institute; Scripps Research Institute; International AIDS Vaccine Initiative; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Duke University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13337
• DOI: 10.1126/science.abn8934
• 发表日期: 2023-01-27
• 页码: 350-+
• 关键词: germinal-centers; lymph-nodes; hiv; expression; responses; affinity; precursors; selection; kinetics; DESIGN