Independent effects of the human circadian system and sleep/ eating cycles on caloric intake in adolescents vary by weight status

• 成果类型: Article
• 署名作者: Barker, David H.; Carskadon, Mary A.; Ardito, Caroline Gredvig-; Hart, Chantelle N.; Raynor, Hollie A.; Scheer, Frank A. J. L.
• 署名单位: Brown University; Brown University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Tennessee System; University of Tennessee Knoxville; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10593
• DOI: 10.1073/pnas.2407907122
• 发表日期: 2025-02-25
• 关键词: food-intake; increases hunger; dim light; obesity; patterns; rhythm; overweight; meal; diet

摘要

Late- day eating is linked to increased obesity risk; however, whether the endogenous circadian system independently influences caloric intake and if this control differs among individuals based on weight status is unknown. Here, we investigated in adolescents the independent roles of the endogenous circadian system and of the behavioral sleep/wake and female adolescents across three weight status categories (24 with healthy weight, 13 with overweight, and 14 with obesity) completed the protocol where participants lived on seven 28- h sleep/wake cycles in dim light during wake and complete darkness during sleep. Results suggest that the circadian system and the behavioral cycle each affected caloric intake, with a decrease across the wake episode and an increase from circadian morning to circadian evening in caloric intake. The endogenous circadian rhythm in caloric intake showed a circadian peak- to- trough difference of 196 [CI 95% 164, 226] kcal per meal with peak timing of 296 degrees [288 degrees, 304 degrees; equivalent to similar to 17:30 in these participants]. In those with overweight/obesity, more calories were consumed later in the waking episode and later in the circadian cycle, and with blunted amplitudes compared results help explain the increased drive for caloric intake toward the evening, especially in those at risk for obesity.