Encoding of environmental illumination by primate melanopsin neurons

• 成果类型: Article
• 署名作者: Liu, Andreas; Milner, Elliott S.; Peng, Yi-Rong; Blume, Hannah A.; Brown, Michael C.; Bryman, Gregory S.; Emanuel, Alan J.; Morquette, Philippe; Viet, Nguyen -Minh; Sanes, Joshua R.; Gamlin, Paul D.; Do, Michael Tri H.
• 署名单位: Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University; University of Alabama System; University of Alabama Birmingham; University of London; University College London; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Merck & Company; Merck & Company USA; Emory University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9296
• DOI: 10.1126/science.ade2024
• 发表日期: 2023-01-27
• 页码: 376-381
• 关键词: expressing ganglion-cells; photoreceptors; responses; macaque; light

摘要

Light regulates physiology, mood, and behavior through signals sent to the brain by intrinsically photosensitive retinal ganglion cells (ipRGCs). How primate ipRGCs sense light is unclear, as they are rare and challenging to target for electrophysiological recording. We developed a method of acute identification within the live, ex vivo retina. Using it, we found that ipRGCs of the macaque monkey are highly specialized to encode irradiance (the overall intensity of illumination) by blurring spatial, temporal, and chromatic features of the visual scene. We describe mechanisms at the molecular, cellular, and population scales that support irradiance encoding across orders-of-magnitude changes in light intensity. These mechanisms are conserved quantitatively across the similar to 70 million years of evolution that separate macaques from mice.