A shift in the mechanisms controlling hippocampal engram formation during brain maturation

• 成果类型: Article
• 署名作者: Ramsaran, Adam I.; Wang, Ying; Golbabaei, Ali; Aleshin, Stepan; de Snoo, Mitchell L.; Yeung, Bi-ru Amy; Rashid, Asim J.; Awasthi, Ankit; Lau, Jocelyn; Tran, Lina M.; Ko, Sangyoon Y.; Abegg, Andrin; Duan, Lana Chunan; McKenzie, Cory; Gallucci, Julia; Ahmed, Moriam; Kaushik, Rahul; Dityatev, Alexander; Josselyn, Sheena A.; Frankland, Paul W.
• 署名单位: University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Toronto; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); Vector Institute for Artificial Intelligence; Swiss Federal Institutes of Technology Domain; ETH Zurich; Otto von Guericke University; Canadian Institute for Advanced Research (CIFAR); Canadian Institute for Advanced Research (CIFAR); University of Zurich; University of Zurich; University of Toronto; Centre for Addiction & Mental Health - Canada
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8616
• DOI: 10.1126/science.ade6530
• 发表日期: 2023-05-05
• 页码: 543-551
• 关键词: long-term potentiation; synaptic plasticity; episodic memory; critical period; subpopulations; reactivation; COMPETITION; inhibition; retrieval

摘要

The ability to form precise, episodic memories develops with age, with young children only able to form gist-like memories that lack precision. The cellular and molecular events in the developing hippocampus that underlie the emergence of precise, episodic-like memory are unclear. In mice, the absence of a competitive neuronal engram allocation process in the immature hippocampus precluded the formation of sparse engrams and precise memories until the fourth postnatal week, when inhibitory circuits in the hippocampus mature. This age-dependent shift in precision of episodic-like memories involved the functional maturation of parvalbumin-expressing interneurons in subfield CA1 through assembly of extracellular perineuronal nets, which is necessary and sufficient for the onset of competitive neuronal allocation, sparse engram formation, and memory precision.