Mapping SARS-CoV-2 antigenic relationships and serological responses

• 成果类型: Article
• 署名作者: Wilks, Samuel H.; Muehlemann, Barbara; Shen, Xiaoying; Tuereli, Sina; LeGresley, Eric B.; Netzl, Antonia; Caniza, Miguela A.; Chacaltana-Huarcaya, Jesus N.; Corman, Victor M.; Daniell, Xiaoju; Datto, Michael B.; Dawood, Fatimah S.; Denny, Thomas N.; Drosten, Christian; Fouchier, Ron A. M.; Garcia, Patricia J.; Halfmann, Peter J.; Jassem, Agatha; Jeworowski, Lara M.; Jones, Terry C.; Kawaoka, Yoshihiro; Krammer, Florian; McDanal, Charlene; Pajon, Rolando; Simon, Viviana; Stockwell, Melissa S.; Tang, Haili; van Bakel, Harm; Veguilla, Vic; Webby, Richard; Montefiori, David C.; Smith, Derek J.
• 署名单位: University of Cambridge; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; German Center for Infection Research; Duke University; Duke University; St Jude Children's Research Hospital; Duke University; Centers for Disease Control & Prevention - USA; Erasmus University Rotterdam; Erasmus MC; Universidad Peruana Cayetano Heredia; University of Wisconsin System; University of Wisconsin Madison; BC Centre for Disease Control; University of Tokyo; University of Tokyo; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Columbia University; Icahn School of Medicine at Mount Sinai; St Jude Children's Research Hospital
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13691
• DOI: 10.1126/science.adj0070
• 发表日期: 2023-10-06
• 页码: 68-+
• 关键词: binding site determine; antibody-responses; genetic evolution; equine influenza; dengue viruses; infection; receptor; neutralization; substitutions; vaccine

摘要

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)-1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.