Protons are the new first responders Human STING's newfound function as a channel expands our understanding of immunity

• 成果类型: Editorial Material
• 署名作者: Liu, Bingxu
• 署名单位: University of Washington; University of Washington Seattle
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11453
• DOI: 10.1126/science.adn9407
• 发表日期: 2024-02-16
• 页码: 713-714
• 关键词: receptors

摘要

Detection and clearance of invading pathogens are crucial for maintaining homeostasis in living systems, from bacteria to humans. First proposed by Charles Janeway in 1989, multiple sensors for sensing pathogen-associated molecular patterns (PAMPs) have now been discovered experimentally. Owing to the diversity of pathogens, human immune systems exhibit remarkable creativity in their detection of various PAMPs. The immune system can sense a wide spectrum of danger signals, which encompass macromolecular double-stranded DNA (dsDNA), lipopolysaccharides, flagellin proteins, and small molecules such as cyclic dinucleotides from bacteria. The varied sensors of these particular signals typically converge in their downstream effects, for example, activation of nuclear factor kappa B (NF-kappa B) or interferon pathways (1, 2).