Developing transmissible vaccines for animal infections

• 成果类型: Editorial Material
• 署名作者: Streicker, Daniel G.; Griffiths, Megan E.; Antia, Rustom; Bergner, Laura; Bowman, Peter; de Moraes, Maria Vitoria dos Santos; Esvelt, Kevin; Famulare, Mike; Gilbert, Amy; He, Biao; Jarvis, Michael A.; Kennedy, David A.; Kuzma, Jennifer; Wanyonyi, Carolyne Nasimiyu; Remien, Christopher; Rocke, Tonie; Rosenke, Kyle; Schreiner, Courtney; Sheen, Justin; Simons, David; Yordanova, Ivet A.; Bull, James J.; Nuismer, Scott L.
• 署名单位: University of Glasgow; University of Glasgow; Emory University; University of California System; University of California Davis; Universidade de Sao Paulo; Massachusetts Institute of Technology (MIT); Bill & Melinda Gates Foundation; United States Department of Agriculture (USDA); University System of Georgia; University of Georgia; University of Plymouth; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; North Carolina State University; North Carolina State University; Washington State University; University of Idaho; United States Department of the Interior; United States Geological Survey; University of Tennessee System; University of Tennessee Knoxville; Princeton University; University of London; University of London Royal Veterinary College; Robert Koch Institute; University of Idaho
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-14036
• DOI: 10.1126/science.adn3231
• 发表日期: 2024-04-19
• 页码: 275-277

摘要

Many emerging and reemerging pathogens originate from wildlife, but nearly all wild species are unreachable using conventional vaccination, which requires capture of and vaccine administration to individual animals. By enabling immunization at scales sufficient to interrupt pathogen transmission, transmissible vaccines (TVs) that spread themselves through wildlife populations by infectious processes could potentially transform the management of otherwise intractable challenges to public health, wildlife conservation, and animal welfare. However, generating TVs likely requires modifying viruses that would be intended to spread in nature, which raises concerns ranging from technical feasibility, to safety and security risks, to regulatory uncertainties ( 1 , 2 ). We propose a series of commitments and strategies for vaccine development-beginning with a priori decisions on vaccine design and continuing through to stakeholder codevelopment [see supplementary materials (SM)]-that we believe increase the likelihood that the potential risks of vaccine transmission are outweighed by benefits to conservation, animal welfare, and zoonosis prevention.