Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts

• 成果类型: Article
• 署名作者: Opulente, Dana A.; Labella, Abigail Leavitt; Harrison, Marie-Claire; Wolters, John F.; Liu, Chao; Li, Yonglin; Kominek, Jacek; Steenwyk, Jacob L.; Stoneman, Hayley R.; Vandenavond, Jenna; Miller, Caroline R.; Langdon, Quinn K.; Silva, Margarida; Goncalves, Carla; Ubbelohde, Emily J.; Li, Yuanning; Buh, Kelly V.; Jarzyna, Martin; Haase, Max A. B.; Rosa, Carlos A.; Cadez, Neza; Libkind, Diego; Devirgilio, Jeremy H.; Hulfachor, Amanda Beth; Kurtzman, Cletus P.; Sampaio, Jose Paulo; Goncalves, Paula; Zhou, Xiaofan; Shen, Xing-Xing; Groenewald, Marizeth; Rokas, Antonis; Hittinger, Chris Todd
• 署名单位: University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; United States Department of Energy (DOE); Villanova University; Vanderbilt University; Vanderbilt University; University of North Carolina; University of North Carolina Charlotte; Zhejiang University; Zhejiang University; South China Agricultural University; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Colorado System; University of Colorado Anschutz Medical Campus; Universidade Nova de Lisboa; Universidade Nova de Lisboa; Shandong University; Laoshan Laboratory; Washington University (WUSTL); Washington University (WUSTL); NYU Langone Medical Center; NYU Langone Medical Center; Max Planck Society; Universidade Federal de Minas Gerais; University of Ljubljana; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad Nacional del Comahue; United States Department of Agriculture (USDA); USDA Agricultural Research Service
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10788
• DOI: 10.1126/science.adj4503
• 发表日期: 2024-04-26
• 关键词: carnitine-dependent transport; candida-albicans; sp nov.; sequence; gene; cerevisiae; EVOLUTION; pathogenicity; reveals; fungi

摘要

Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance efficiency and breadth and (ii) the joint influence of extrinsic (environmental) and intrinsic (genomic) factors. We assembled genomic, metabolic, and ecological data from nearly all known species of the ancient fungal subphylum Saccharomycotina (1154 yeast strains from 1051 species), grown in 24 different environmental conditions, to examine niche breadth evolution. We found that large differences in the breadth of carbon utilization traits between yeasts stem from intrinsic differences in genes encoding specific metabolic pathways, but we found limited evidence for trade-offs. These comprehensive data argue that intrinsic factors shape niche breadth variation in microbes.