Brain-muscle communication prevents muscle aging by maintaining daily physiology

• 成果类型: Article
• 署名作者: Kumar, Arun; Vaca-Dempere, Mireia; Mortimer, Thomas; Deryagin, Oleg; Smith, Jacob G.; Petrus, Paul; Koronowski, Kevin B.; Greco, Carolina M.; Segales, Jessica; Andres, Eva; Lukesova, Vera; Zinna, Valentina M.; Welz, Patrick-Simon; Serrano, Antonio L.; Perdiguero, Eusebio; Sassone-Corsi, Paolo; Benitah, Salvador Aznar; Munoz-Canoves, Pura
• 署名单位: Pompeu Fabra University; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; University of Texas System; University of Texas at San Antonio; Karolinska Institutet; Humanitas University; Hospital del Mar Research Institute; Hospital del Mar; ICREA
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10785
• DOI: 10.1126/science.adj8533
• 发表日期: 2024-05-03
• 页码: 563-572
• 关键词: peripheral circadian clocks; age-related decline; suprachiasmatic nucleus; skeletal-muscle; gene-expression; liver; metabolism; cells; Visualization; component

摘要

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.