Recyclable surgical, consumer, and industrial adhesives of poly(α-lipoic acid)

• 成果类型: Article
• 署名作者: Pal, Subhajit; Shin, Jisoo; Defrates, Kelsey; Arslan, Mustafa; Dale, Katelyn; Chen, Hannah; Ramirez, Dominic; Messersmith, Phillip B.
• 署名单位: University of California System; University of California Berkeley; Kirklareli University; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10764
• DOI: 10.1126/science.ado6292
• 发表日期: 2024-08-23
• 页码: 877-883
• 关键词: polymers; surgery

摘要

Polymer adhesives play an important role in many medical, consumer, and industrial products. Polymers of alpha-lipoic acid (alpha LA) have the potential to fulfill the need for versatile and environmentally friendly adhesives, but their performance is plagued by spontaneous depolymerization. We report a family of stabilized alpha LA polymer adhesives that can be tailored for a variety of medical or nonmedical uses and sustainably sourced and recycled in a closed-loop manner. Minor changes in monomer composition afforded a pressure-sensitive adhesive that functions well in dry and wet conditions, as well as a structural adhesive with strength equivalent to that of conventional epoxies. alpha LA surgical superglue successfully sealed murine amniotic sac ruptures, increasing fetal survival from 0 to 100%.