A smart mask for exhaled breath condensate harvesting and analysis

• 成果类型: Article
• 署名作者: Heng, Wenzheng; Yin, Shukun; Min, Jihong; Wang, Canran; Han, Hong; Sani, Ehsan Shirzaei; Li, Jiahong; Song, Yu; Rossiter, Harry B.; Gao, Wei
• 署名单位: California Institute of Technology; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13437
• DOI: 10.1126/science.adn6471
• 发表日期: 2024-08-30
• 页码: 954-961
• 关键词: obstructive sleep-apnea; nitric-oxide; oxidative stress; electronic nose; asthma; 8-isoprostane; management; diagnosis; sensor; feno

摘要

Recent respiratory outbreaks have garnered substantial attention, yet most respiratory monitoring remains confined to physical signals. Exhaled breath condensate (EBC) harbors rich molecular information that could unveil diverse insights into an individual's health. Unfortunately, challenges related to sample collection and the lack of on-site analytical tools impede the widespread adoption of EBC analysis. Here, we introduce EBCare, a mask-based device for real-time in situ monitoring of EBC biomarkers. Using a tandem cooling strategy, automated microfluidics, highly selective electrochemical biosensors, and a wireless reading circuit, EBCare enables continuous multimodal monitoring of EBC analytes across real-life indoor and outdoor activities. We validated EBCare's usability in assessing metabolic conditions and respiratory airway inflammation in healthy participants, patients with chronic obstructive pulmonary disease or asthma, and patients after COVID-19 infection.