Chemical genetic approaches to dissect microbiota mechanisms in health and disease

• 成果类型: Review
• 署名作者: Yang, Xinglin; Hang, Howard C.
• 署名单位: Scripps Research Institute; Scripps Research Institute; Peking University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12191
• DOI: 10.1126/science.ado8548
• 发表日期: 2024-11-15
• 关键词: pattern-recognition receptors; adjuvant activity; gut microbiome; peptidoglycan; GROWTH; bacteria; reveals; cancer; DISCOVERY; causation

摘要

Advances in genomics, proteomics, and metabolomics have revealed associations between specific microbiota species in health and disease. However, the precise mechanism(s) of action for many microbiota species and molecules have not been fully elucidated, limiting the development of microbiota-based diagnostics and therapeutics. In this Review, we highlight innovative chemical and genetic approaches that are enabling the dissection of microbiota mechanisms and providing causation in health and disease. Although specific microbiota molecules and mechanisms have begun to emerge, new approaches are still needed to go beyond phenotypic associations and translate microbiota discoveries into actionable targets and therapeutic leads to prevent and treat diseases.