Local genetic adaptation to habitat in wild chimpanzees

• 成果类型: Article
• 署名作者: Ostridge, Harrison J.; Fontsere, Claudia; Lizano, Esther; Soto, Daniela C.; Schmidt, Joshua M.; Saxena, Vrishti; Alvarez-Estape, Marina; Barratt, Christopher D.; Gratton, Paolo; Bocksberger, Gaelle; Lester, Jack D.; Dieguez, Paula; Agbor, Anthony; Angedakin, Samuel; Assumang, Alfred Kwabena; Bailey, Emma; Barubiyo, Donatienne; Bessone, Mattia; Brazzola, Gregory; Chancellor, Rebecca; Cohen, Heather; Coupland, Charlotte; Danquah, Emmanuel; Deschner, Tobias; Dotras, Laia; Dupain, Jef; Egbe, Villard Ebot; Granjon, Anne-Celine; Head, Josephine; Hedwig, Daniela; Hermans, Veerle; Hernandez-Aguilar, R. Adriana; Jeffery, Kathryn J.; Jones, Sorrel; Junker, Jessica; Kadam, Parag; Kaiser, Michael; Kalan, Ammie K.; Kambere, Mbangi; Kienast, Ivonne; Kujirakwinja, Deo; Langergraber, Kevin E.; Lapuente, Juan; Larson, Bradley; Laudisoit, Anne; Lee, Kevin C.; Llana, Manuel; Maretti, Giovanna; Martin, Rumen; Meier, Amelia C.; Morgan, David; Neil, Emily; Nicholl, Sonia; Nixon, Stuart; Normand, Emmanuelle; Orbell, Christopher; Ormsby, Lucy Jayne; Orume, Robinson; Pacheco, Liliana; Preece, Jodie; Regnaut, Sebastien; Robbins, Martha M.; Rundus, Aaron; Sanz, Crickette; Sciaky, Lilah; Sommer, Volker; Stewart, Fiona A.; Tagg, Nikki; Tedonzong, Luc Roscelin; van Schijndel, Joost; Vendras, Elleni; Wessling, Erin G.; Willie, Jacob; Wittig, Roman M.; Yuh, Yisa Ginath; Yurkiw, Kyle; Vigilant, Linda; Piel, Alex K.; Boesch, Christophe; Kuhl, Hjalmar S.; Dennis, Megan Y.; Marques-Bonet, Tomas; Arandjelovic, Mimi; Andres, Aida M.
• 署名单位: University of London; University College London; University of Copenhagen; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Barcelona Biomedical Research Park; University of California System; University of California Davis; Flinders University South Australia; Naturalis Biodiversity Center; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); University of Rome Tor Vergata; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Senckenberg Biodiversitat & Klima- Forschungszentrum (BiK-F); Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Kwame Nkrumah University Science & Technology; University of Konstanz; Pennsylvania State System of Higher Education (PASSHE); West Chester University of Pennsylvania; Martin Luther University Halle Wittenberg; University Osnabruck; University of Barcelona; Leipzig University; Cornell University; University of Stirling; University of Victoria; Cornell University; Cornell University; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; EcoHealth Alliance; University of Antwerp; University of Hawaii System; University of Hawaii Manoa; Washington University (WUSTL); University of London; University College London; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of Gottingen; Ghent University; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre Suisse de Recherches Scientifiques en Cote d'Ivoire (CSRS); Technische Universitat Dresden; ICREA; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Autonomous University of Barcelona; Institut Catala de Paleontologia Miquel Crusafont (ICP)
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10931
• DOI: 10.1126/science.adn7954
• 发表日期: 2025-01-10
• 关键词: immunodeficiency virus-infection; natural-selection; pan-troglodytes; soft sweeps; signatures; EVOLUTION; malaria; aids; erythrocytes; association

摘要

How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process, especially for endangered species, such as nonhuman great apes. Chimpanzees, our closest living relatives, are particularly notable because they inhabit diverse habitats, from rainforest to woodland-savannah. Whether genetic adaptation facilitates such habitat diversity remains unknown, despite it having wide implications for evolutionary biology and conservation. By using newly sequenced exomes from 828 wild chimpanzees (388 postfiltering), we found evidence of fine-scale genetic adaptation to habitat, with signatures of positive selection in forest chimpanzees in the same genes underlying adaptation to malaria in humans. This work demonstrates the power of noninvasive samples to reveal genetic adaptations in endangered populations and highlights the importance of adaptive genetic diversity for chimpanzees.