Rapid and dynamic evolution of a giant Y chromosome in Silene latifolia

• 成果类型: Article
• 署名作者: Akagi, Takashi; Fujita, Naoko; Shirasawa, Kenta; Tanaka, Hiroyuki; Nagaki, Kiyotaka; Masuda, Kanae; Horiuchi, Ayano; Kuwada, Eriko; Kawai, Kanta; Kunou, Riko; Nakamura, Koki; Ikeda, Yoko; Toyoda, Atsushi; Itoh, Takehiko; Ushijima, Koichiro; Charlesworth, Deborah
• 署名单位: Okayama University; Japan Science & Technology Agency (JST); Yokohama City University; National Museum of Nature and Science; Kazusa DNA Research Institute; Institute of Science Tokyo; Tokyo Institute of Technology; Okayama University; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; University of Edinburgh
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12811
• DOI: 10.1126/science.adk9074
• 发表日期: 2025-02-07
• 页码: 637-643
• 关键词: sex-chromosomes; dna; degeneration; alignment; regions; genes; tool; arabidopsis; accurate; program

摘要

Some plants have massive sex-linked regions. To test hypotheses about their evolution, we sequenced the genome of Silene latifolia, in which giant heteromorphic sex chromosomes were first discovered in 1923. It has long been known that the Y chromosome consists mainly of a male-specific region that does not recombine with the X chromosome and carries the sex-determining genes and genes with other male functions. However, only with a whole Y chromosome assembly can candidate genes be validated experimentally and their locations determined and related to the suppression of recombination. We describe the genomic changes as the ancestral chromosome evolved into the current XY pair, testing ideas about the evolution of large nonrecombining regions and the mechanisms that created the present recombination pattern.