Evolutionary convergence of sensory circuits in the pallium of amniotes

• 成果类型: Article
• 署名作者: Rueda-Alana, Eneritz; Senovilla-Ganzo, Rodrigo; Grillo, Marco; Vazquez, Enrique; Marco-Salas, Sergio; Gallego-Flores, Tatiana; Ordenana-Manso, Aitor; Ftara, Artemis; Escobar, Laura; Benguria, Alberto; Quintas, Ana; Dopazo, Ana; Rabano, Miriam; Vivanco, Maria dM; Aransay, Ana Maria; Garrigos, Daniel; Toval, Angel; Ferran, Jose Luis; Nilsson, Mats; Encinas-Perez, Juan Manuel; De Pitta, Maurizio; Garcia-Moreno, Fernando
• 署名单位: University of Basque Country; Stockholm University; Centro Nacional de Investigaciones Cardiovasculares (CNIC); CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; CIC bioGUNE; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University of Murcia; Basque Foundation for Science; Basque Center for Applied Mathematics (BCAM); Krembil Research Institute; University of Toronto; University Health Network Toronto; University of Toronto
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10727
• DOI: 10.1126/science.adp3411
• 发表日期: 2025-02-14
• 页码: 732-+
• 关键词: dorsal ventricular ridge; cortical-neurons; telencephalic connections; avian telencephalon; cerebral-cortex; cell-migration; brain; mouse; projections; ORGANIZATION

摘要

The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA and spatial transcriptomics, and mathematical modeling to compare the development and evolution of known pallial circuits across birds (chick), lizards (gecko), and mammals (mouse). We reveal that neurons within these circuits' stations are generated at varying developmental times and brain regions across species and found an early developmental divergence in the transcriptomic progression of glutamatergic neurons. Our research highlights developmental distinctions and functional similarities in the sensory circuit between birds and mammals, suggesting the convergence of high-order sensory processing across amniote lineages.