Adaptation repeatedly uses complex structural genomic variation

• 成果类型: Article
• 署名作者: Gompert, Zachariah; Feder, Jeffrey L.; Parchman, Thomas L.; Planidin, Nicholas P.; Whiting, Frederick J. H.; Nosil, Patrik
• 署名单位: Utah System of Higher Education; Utah State University; University of Notre Dame; Nevada System of Higher Education (NSHE); University of Nevada Reno; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10714
• DOI: 10.1126/science.adp3745
• 发表日期: 2025-04-18
• 关键词: local adaptation; gene flow; reproductive isolation; natural-selection; divergence; EVOLUTION; inversions; CONSEQUENCES; polymorphism; chromosomes

摘要

Structural elements are widespread across genomes, but their complexity and role in repeatedly driving local adaptation remain unclear. In this work, we use phased genome assemblies to show that adaptive divergence in cryptic color pattern in a stick insect is repeatedly underlain by structural variation, but not a simple chromosomal inversion. We found that color pattern in populations of stick insects on two mountains is associated with translocations that have also been inverted. These translocations differ in size and origin on each mountain, but they overlap partially and involve some of the same gene regions. Moreover, this structural variation is subject to divergent selection and arose without introgression between species. Our results show how the origin of structural variation provides a mechanism for repeated bouts of adaptation.