Antagonism as a foraging strategy in microbial communities

• 成果类型: Article
• 署名作者: Stubbusch, Astrid K. M.; Peaudecerf, Francois J.; Lee, Kang Soo; Paoli, Lucas; Schwartzman, Julia; Stocker, Roman; Basler, Marek; Schubert, Olga T.; Ackermann, Martin; Magnabosco, Cara; D'Souza, Glen G.
• 署名单位: Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Swiss Federal Institutes of Technology Domain; ETH Zurich; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Universite de Rennes; Swiss Federal Institutes of Technology Domain; ETH Zurich; Ulsan National Institute of Science & Technology (UNIST); Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Southern California; University of Basel; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9324
• DOI: 10.1126/science.adr8286
• 发表日期: 2025-06-12
• 页码: 1214-1217
• 关键词: vi secretion system; escherichia-coli; bacteria; genome; GROWTH; cells; tool

摘要

In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependent antagonism. Using single-cell live imaging and isotopic markers, we found that during starvation, the type VI secretion system (T6SS) lysed neighboring cells and thus provided nutrients from lysing cells for growth. Genomic adaptations in antagonists, characterized by a reduced metabolic gene repertoire, and the previously unexplored distribution of the T6SS across bacterial taxa in natural environments suggest that bacterial antagonism may contribute to nutrient transfer within microbial communities in many ecosystems.