Tissue-integrated bionic knee restores versatile legged movement after amputation

• 成果类型: Article
• 署名作者: Shu, Tony; Levine, Daniel; Yeon, Seong Ho; Chun, Ethan; Shallal, Christopher C.; McCullough, John; Branemark, Rickard; Carty, Matthew J.; Ferrone, Marco; Boerhout, Sean; Ko, Alexander; Sullivan, Corey L.; Zhu, Gloria; Nawrot, Michael; Carney, Matthew; Wieschhoff, Ged; Friedman, Gabriel; Herr, Hugh
• 署名单位: Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Gothenburg; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12147
• DOI: 10.1126/science.adv3223
• 发表日期: 2025-07-10
• 关键词: muscle; prosthesis; ambulation; humans; walk

摘要

Lower-extremity prostheses have evolved through mechanical redesigns that prioritize improved cyclic locomotion. However, this limited approach to limb restoration has precluded necessary progress toward recovering the versatile acyclic movements that constitute the remainder of human athleticism. We present an osseointegrated mechanoneural prosthesis that incorporates modified hard and soft tissues along with permanently implanted hardware in a neuroembodied design. We developed a biomimetic coupling between neuromuscular signaling and joint movement that exceeds the versatility of established control methods, which depend upon conventional amputation musculature and surface electromyography. Our findings also reveal that superior residual neuromuscular function can enable prosthetic movement speeds surpassing that of intact physiology. Anatomical prosthetic integration may be necessary for meeting, and possibly exceeding, the movement capabilities of an intact limb.