Radular teeth matrix protein 1 directs iron oxide deposition in chiton teeth

• 成果类型: Article
• 署名作者: Nemoto, Michiko; Okada, Koki; Akamine, Haruka; Odagaki, Yuki; Narahara, Yuka; Okoshi, Kenji; Obuse, Kiori; Kisailus, David; Moriya, Hisao; Satoh, Akira
• 署名单位: Okayama University; Okayama University; Toho University; University of California System; University of California Irvine; University of California System; University of California Irvine; Okayama University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11542
• DOI: 10.1126/science.adu0043
• 发表日期: 2025-08-07
• 页码: 637-643
• 关键词: ferric hydroxide; fast program; web server; alignment; silica; biomineralization; magnetite; cleavage; bacteria; diatom

摘要

Nature builds multiscale mineral structures with impressive mechanical properties through spatially and temporally orchestrated organic-mineral assembly. One example of regulated mineralization is found in hypermineralized and ultrahard magnetic teeth of chiton, which grind on rock to feed on algae. At early stages of tooth formation, iron oxide deposition is controlled using a chiton-specific radular teeth matrix protein 1 (RTMP1), which is transported into teeth through microvilli. RTMP1 spatially and temporally guides and enhances mineralization on chitinous fibers within the tooth, providing a hard, tough, and strong architecture that enables the organism to perform repetitive abrasive events to survive.